About: Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives

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About: Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aortic dissection (AD) is a severe vascular disease associated with major morbidity and mortality. The diagnosis of AD requires the performance of urgent aortic imaging exams such as computed tomography angiography, but the decision to perform these exams now essentially relies on clinical judgment. Several studies have identified a range of potential biomarkers stemming from the aortic extracellular matrix (matrix metalloproteinases, TGF-beta, soluble elastin fragments), vascular smooth muscle cells (smooth muscle myosin heavy chain, creatine kinase, calponin), coagulation (d-dimer, platelets) and inflammation (C-reactive protein), whose circulating levels increase in patients affected by AD. Biomarkers of AD could be potentially used to screen patients with compatible symptoms, to identify patients at higher risk of AD, to rule out AD in patients with non-high clinical probability of AD and/or to obtain prognostic stratification of affected patients. This review will summarize available data and discuss present and future perspectives of circulating biomarkers for the diagnosis and prognostic stratification of AD. Aortic dissection (AD) is a severe vascular disease associated with major morbidity and mortality. The diagnosis of AD requires the performance of urgent aortic imaging exams such as computed tomography angiography, but the decision to perform these exams now essentially relies on clinical judgment. Several studies have identified a range of potential biomarkers stemming from the aortic extracellular matrix (matrix metalloproteinases, TGF-beta, soluble elastin fragments), vascular smooth muscle cells (smooth muscle myosin heavy chain, creatine kinase, calponin), coagulation (d-dimer, platelets) and inflammation (C-reactive protein), whose circulating levels increase in patients affected by AD. Biomarkers of AD could be potentially used to screen patients with compatible symptoms, to identify patients at higher risk of AD, to rule out AD in patients with non-high clinical probability of AD and/or to obtain prognostic stratification of affected patients. This review will summarize available data and discuss present and future perspectives of circulating biomarkers for the diagnosis and prognostic stratification of AD. (en)
Title	Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives (en)
skos:prefLabel	Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives (en)
skos:notation	RIV/00159816:_____/14:00061213!RIV15-MSM-00159816
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Piler, Pavel Kružliak, Peter Novák, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice u sv.Anny v Brně
http://linked.open...dnocenehoVysledku	5430
http://linked.open...ai/riv/idVysledku	RIV/00159816:_____/14:00061213
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platelets; myosin; matrix metalloproteinase; elastin; diagnosis; d-dimer; calponin creatinine kinase; biomarker; aortic dissection; C-reactive protein (en)
http://linked.open.../riv/klicoveSlovo	C-reactive protein myosin elastin d-dimer diagnosis aortic dissection matrix metalloproteinase calponin creatinine kinase biomarker platelets
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E10F72093313]
http://linked.open...i/riv/nazevZdroje	Biomarkers in Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Novák, Miroslav Kružliak, Peter Piler, Pavel Morello, F.
http://linked.open...ain/vavai/riv/wos	000343183100003
issn	1752-0363
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.2217/bmm.14.38

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