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Description
| - Microspheres (μS) reach intracranial occlusions and transmit energy momentum from an ultrasound wave to residual flow to promote recanalization. We report a randomized multicenter phase II trial of μS dose escalation with systemic thrombolysis. Methods: Stroke patients receiving 0.9mg/kg tissue plasminogen activator (tPA) with pretreatment proximal intracranial occlusions on transcranial Doppler (TCD) were randomized (2:1 ratio) to μS (MRX-801) infusion over 90 minutes (Cohort 1, 1.4ml; Cohort 2, 2.8ml) with continuous TCD insonation, whereas controls received tPA and brief TCD assessments. The primary endpoint was symptomatic intracerebral hemorrhage (sICH) within 36 hours after tPA.
- Microspheres (μS) reach intracranial occlusions and transmit energy momentum from an ultrasound wave to residual flow to promote recanalization. We report a randomized multicenter phase II trial of μS dose escalation with systemic thrombolysis. Methods: Stroke patients receiving 0.9mg/kg tissue plasminogen activator (tPA) with pretreatment proximal intracranial occlusions on transcranial Doppler (TCD) were randomized (2:1 ratio) to μS (MRX-801) infusion over 90 minutes (Cohort 1, 1.4ml; Cohort 2, 2.8ml) with continuous TCD insonation, whereas controls received tPA and brief TCD assessments. The primary endpoint was symptomatic intracerebral hemorrhage (sICH) within 36 hours after tPA. (en)
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Title
| - Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial
- Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial (en)
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skos:prefLabel
| - Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial
- Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial (en)
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skos:notation
| - RIV/00159816:_____/09:#0000417!RIV10-MZ0-00159816
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00159816:_____/09:#0000417
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Clinical trial; Ultrasound; ervous system diseases (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Mikulík, Robert
- Molina, C. A.
- Alexandrov, A. V.
- Grotta, J. C.
- Schellinger, P. D.
- Tsivgoulis, G.
- Bareeto, A. D.
- Gonzales, N.
- Malkoff, M. D.
- Manvelian, G.
- Ostrem, J.
- Pate, G.
- Rubiera, M.
- Sierzenski, P.
- Singleton, W.
- Unger, E. C.
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issn
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number of pages
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