About: Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Microspheres (μS) reach intracranial occlusions and transmit energy momentum from an ultrasound wave to residual flow to promote recanalization. We report a randomized multicenter phase II trial of μS dose escalation with systemic thrombolysis. Methods: Stroke patients receiving 0.9mg/kg tissue plasminogen activator (tPA) with pretreatment proximal intracranial occlusions on transcranial Doppler (TCD) were randomized (2:1 ratio) to μS (MRX-801) infusion over 90 minutes (Cohort 1, 1.4ml; Cohort 2, 2.8ml) with continuous TCD insonation, whereas controls received tPA and brief TCD assessments. The primary endpoint was symptomatic intracerebral hemorrhage (sICH) within 36 hours after tPA. Microspheres (μS) reach intracranial occlusions and transmit energy momentum from an ultrasound wave to residual flow to promote recanalization. We report a randomized multicenter phase II trial of μS dose escalation with systemic thrombolysis. Methods: Stroke patients receiving 0.9mg/kg tissue plasminogen activator (tPA) with pretreatment proximal intracranial occlusions on transcranial Doppler (TCD) were randomized (2:1 ratio) to μS (MRX-801) infusion over 90 minutes (Cohort 1, 1.4ml; Cohort 2, 2.8ml) with continuous TCD insonation, whereas controls received tPA and brief TCD assessments. The primary endpoint was symptomatic intracerebral hemorrhage (sICH) within 36 hours after tPA. (en)
Title	Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial (en)
skos:prefLabel	Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial (en)
skos:notation	RIV/00159816:_____/09:#0000417!RIV10-MZ0-00159816
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Mikulík, Robert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice u sv.Anny v Brně
http://linked.open...dnocenehoVysledku	346684
http://linked.open...ai/riv/idVysledku	RIV/00159816:_____/09:#0000417
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Clinical trial; Ultrasound; ervous system diseases (en)
http://linked.open.../riv/klicoveSlovo	Ultrasound Clinical trial ervous system diseases
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[39DA659EA7F1]
http://linked.open...i/riv/nazevZdroje	Annals of Neurology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	66
http://linked.open...iv/tvurceVysledku	Mikulík, Robert Molina, C. A. Alexandrov, A. V. Grotta, J. C. Schellinger, P. D. Tsivgoulis, G. Bareeto, A. D. Gonzales, N. Malkoff, M. D. Manvelian, G. Ostrem, J. Pate, G. Rubiera, M. Sierzenski, P. Singleton, W. Unger, E. C.
issn	0364-5134
number of pages	11 (xsd:int)

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