About: Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	20 wilde-type strains of P. aeruginosa forming a 24-hour old biofilm in TSB medium on 96-well polystyren microtiter plates were used. We tested eight antibiotics, namely aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin, individually and in combinations. Minimum biofilm inhibitory concentration (MBIC) and fractionate inhibitory concentration (FBIC) were determined. Although in biofilm was P. aeruginosa less susceptible to antibiotics synergy due to 10 P. aeruginosa isolates were demonstrated for Aztreonam and Ciprofloxacin. Synergy was demonstrated also in case of b-lactams and aminoglycosides, b-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones as well as for monobactams and b-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism against 32.4 % of isolates with one or more antimicrobial combinations was found. 20 wilde-type strains of P. aeruginosa forming a 24-hour old biofilm in TSB medium on 96-well polystyren microtiter plates were used. We tested eight antibiotics, namely aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin, individually and in combinations. Minimum biofilm inhibitory concentration (MBIC) and fractionate inhibitory concentration (FBIC) were determined. Although in biofilm was P. aeruginosa less susceptible to antibiotics synergy due to 10 P. aeruginosa isolates were demonstrated for Aztreonam and Ciprofloxacin. Synergy was demonstrated also in case of b-lactams and aminoglycosides, b-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones as well as for monobactams and b-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism against 32.4 % of isolates with one or more antimicrobial combinations was found. (en)
Title	Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa (en)
skos:prefLabel	Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa Antibiotic synergy against Biofilm-Forming Pseudomonas aeruginosa (en)
skos:notation	RIV/00159816:_____/08:#0000412!RIV10-MZ0-00159816
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NI6818)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Votava, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice u sv.Anny v Brně
http://linked.open...dnocenehoVysledku	356389
http://linked.open...ai/riv/idVysledku	RIV/00159816:_____/08:#0000412
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biofilm , antibioticsm, P. aeruginosa (en)
http://linked.open.../riv/klicoveSlovo	biofilm P. aeruginosa antibioticsm
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[038000E9F2D7]
http://linked.open...i/riv/nazevZdroje	Folia Microbiologica
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Biofilm formation in microbes isolated from clinical materials: the utilization of its detection in practice
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Votava, Miroslav Černohorská, Lenka
issn	0015-5632
number of pages	96 (xsd:int)

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