About: Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma     Goto   Sponge   NotDistinct   Permalink

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  • Recent research suggests that multinodular recurrent pleomorphic adenoma (PA) might result from cell migration through lymphatics. Lymphangiogenesis in malignancies is mediated by vascular endothelial growth factors C and D (VEGF-C/D).We studied the expression of VEGF-C/D in PA by immunohistochemistry as well as lymphatic vessel density (LVD). In 6 non-recurrent, 4 primary-to-recur, and 10 recurrent PAs, VEGF-C/D expression was assessed by immunohistochemistry. Staining was scored in terms of staining intensity (0 = absent to 3 = strong), and the percentage of positive tumor cells (scored as 0 (0–19 %), 1 (20–39 %), 2 (40–50 %), and 3 (60–100 %)) and a sum score were calculated. Intra- and peritumoral LVD was assessed by counting of LV after immunostaining, using the D2-40 antibody. All but one sample were VEGF-C negative. The differences in VEGF-D expression between non-recurrent, primary-torecur, and recurrent PAs were not significant (p >0.05). VEGF-D expression did not correlate with peritumoral LVD (p >0.05). Our study revealed a significant difference between intra- and peritumoral LVD values when comparing individual and all sample groups (p =0.01). The lack of VEGF-C expression and of significant differences in VEGF-D expression and peritumoral LVD between patients with nonrecurrent, primary-to-recur, and recurrent PAs does not support the lymphangiogenic local spread hypothesis
  • Recent research suggests that multinodular recurrent pleomorphic adenoma (PA) might result from cell migration through lymphatics. Lymphangiogenesis in malignancies is mediated by vascular endothelial growth factors C and D (VEGF-C/D).We studied the expression of VEGF-C/D in PA by immunohistochemistry as well as lymphatic vessel density (LVD). In 6 non-recurrent, 4 primary-to-recur, and 10 recurrent PAs, VEGF-C/D expression was assessed by immunohistochemistry. Staining was scored in terms of staining intensity (0 = absent to 3 = strong), and the percentage of positive tumor cells (scored as 0 (0–19 %), 1 (20–39 %), 2 (40–50 %), and 3 (60–100 %)) and a sum score were calculated. Intra- and peritumoral LVD was assessed by counting of LV after immunostaining, using the D2-40 antibody. All but one sample were VEGF-C negative. The differences in VEGF-D expression between non-recurrent, primary-torecur, and recurrent PAs were not significant (p >0.05). VEGF-D expression did not correlate with peritumoral LVD (p >0.05). Our study revealed a significant difference between intra- and peritumoral LVD values when comparing individual and all sample groups (p =0.01). The lack of VEGF-C expression and of significant differences in VEGF-D expression and peritumoral LVD between patients with nonrecurrent, primary-to-recur, and recurrent PAs does not support the lymphangiogenic local spread hypothesis (en)
Title
  • Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma
  • Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma (en)
skos:prefLabel
  • Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma
  • Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma (en)
skos:notation
  • RIV/00098892:_____/13:#0000558!RIV14-MZ0-00098892
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, V
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 91142
http://linked.open...ai/riv/idVysledku
  • RIV/00098892:_____/13:#0000558
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • lymphangiogenesis, pleomorphic adenoma, recurrence, salivary gland, vascular endothelial growth factor (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [7203B9995C2B]
http://linked.open...i/riv/nazevZdroje
  • Virchows Archiv
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 464
http://linked.open...iv/tvurceVysledku
  • Stárek, Ivo
  • Salzman, Richard
issn
  • 0945-6317
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