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Description
| - Recent research suggests that multinodular recurrent pleomorphic adenoma (PA) might result from cell migration through lymphatics. Lymphangiogenesis in malignancies is mediated by vascular endothelial growth factors C and D (VEGF-C/D).We studied the expression of VEGF-C/D in PA by immunohistochemistry as well as lymphatic vessel density (LVD). In 6 non-recurrent, 4 primary-to-recur, and 10 recurrent PAs, VEGF-C/D expression was assessed by immunohistochemistry. Staining was scored in terms of staining intensity (0 = absent to 3 = strong), and the percentage of positive tumor cells (scored as 0 (0–19 %), 1 (20–39 %), 2 (40–50 %), and 3 (60–100 %)) and a sum score were calculated. Intra- and peritumoral LVD was assessed by counting of LV after immunostaining, using the D2-40 antibody. All but one sample were VEGF-C negative. The differences in VEGF-D expression between non-recurrent, primary-torecur, and recurrent PAs were not significant (p >0.05). VEGF-D expression did not correlate with peritumoral LVD (p >0.05). Our study revealed a significant difference between intra- and peritumoral LVD values when comparing individual and all sample groups (p =0.01). The lack of VEGF-C expression and of significant differences in VEGF-D expression and peritumoral LVD between patients with nonrecurrent, primary-to-recur, and recurrent PAs does not support the lymphangiogenic local spread hypothesis
- Recent research suggests that multinodular recurrent pleomorphic adenoma (PA) might result from cell migration through lymphatics. Lymphangiogenesis in malignancies is mediated by vascular endothelial growth factors C and D (VEGF-C/D).We studied the expression of VEGF-C/D in PA by immunohistochemistry as well as lymphatic vessel density (LVD). In 6 non-recurrent, 4 primary-to-recur, and 10 recurrent PAs, VEGF-C/D expression was assessed by immunohistochemistry. Staining was scored in terms of staining intensity (0 = absent to 3 = strong), and the percentage of positive tumor cells (scored as 0 (0–19 %), 1 (20–39 %), 2 (40–50 %), and 3 (60–100 %)) and a sum score were calculated. Intra- and peritumoral LVD was assessed by counting of LV after immunostaining, using the D2-40 antibody. All but one sample were VEGF-C negative. The differences in VEGF-D expression between non-recurrent, primary-torecur, and recurrent PAs were not significant (p >0.05). VEGF-D expression did not correlate with peritumoral LVD (p >0.05). Our study revealed a significant difference between intra- and peritumoral LVD values when comparing individual and all sample groups (p =0.01). The lack of VEGF-C expression and of significant differences in VEGF-D expression and peritumoral LVD between patients with nonrecurrent, primary-to-recur, and recurrent PAs does not support the lymphangiogenic local spread hypothesis (en)
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Title
| - Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma
- Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma (en)
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skos:prefLabel
| - Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma
- Neither expression of VEGF-C/D nor lymph vessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma (en)
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skos:notation
| - RIV/00098892:_____/13:#0000558!RIV14-MZ0-00098892
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00098892:_____/13:#0000558
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - lymphangiogenesis, pleomorphic adenoma, recurrence, salivary gland, vascular endothelial growth factor (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Stárek, Ivo
- Salzman, Richard
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issn
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number of pages
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