About: Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia

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About: Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aims We assessed long-term outcome of consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (INF-?) in Central and Northern Moravia between 1989 and 2006. Methods A retrospective study focused on the response, prognostic factors and side effects of INF-?. Results 118 patients (67 males and 51 females at a median age 50 years; range 18-71) were analyzed. The median follow-up was 82.6 months (12.4-212.6). Thirty-six patients (30.5%) achieved major cytogenetic response (CyR) in median of 18.3 months (3.7-47.3) and maintained it for median of 64.0 months (7.0-176.0). Sixty-one patients treated with INF-? for more than 12 months had overall survival (OS) 137.0 months (95% CI 117.6-156.4). Eighteen (29.5%) of them achieved complete CyR (CCyR). 109 patients discontinued the treatment with INF-? because of hematologic or cytogenetic resistance in 53 (48.7%), progression of CML in 31 (28.4%) and intolerance to INF-? in 17 (15.6%) patients Aims We assessed long-term outcome of consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (INF-?) in Central and Northern Moravia between 1989 and 2006. Methods A retrospective study focused on the response, prognostic factors and side effects of INF-?. Results 118 patients (67 males and 51 females at a median age 50 years; range 18-71) were analyzed. The median follow-up was 82.6 months (12.4-212.6). Thirty-six patients (30.5%) achieved major cytogenetic response (CyR) in median of 18.3 months (3.7-47.3) and maintained it for median of 64.0 months (7.0-176.0). Sixty-one patients treated with INF-? for more than 12 months had overall survival (OS) 137.0 months (95% CI 117.6-156.4). Eighteen (29.5%) of them achieved complete CyR (CCyR). 109 patients discontinued the treatment with INF-? because of hematologic or cytogenetic resistance in 53 (48.7%), progression of CML in 31 (28.4%) and intolerance to INF-? in 17 (15.6%) patients (en)
Title	Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia (en)
skos:prefLabel	Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia (en)
skos:notation	RIV/00098892:_____/13:#0000486!RIV14-MZ0-00098892
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM6198959205), Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Faber, Edgar Rohoň, Peter Divoká, Martina Kuba, Adam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Olomouc
http://linked.open...dnocenehoVysledku	80743
http://linked.open...ai/riv/idVysledku	RIV/00098892:_____/13:#0000486
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chronic myeloid leukemia, interferon-alpha, cytogenetic response (en)
http://linked.open.../riv/klicoveSlovo	cytogenetic response chronic myeloid leukemia interferon-alpha
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CCA738D63EC2]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers-Olomouc
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	157
http://linked.open...iv/tvurceVysledku	Faber, Edgar Rohoň, Peter Divoká, Martina Kuba, Adam
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů
issn	1213-8118
number of pages	9 (xsd:int)

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