About: Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia

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About: Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-α) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4–212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7–40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase–polymerase chain reaction [“complete” molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4–10) years, while 2 continue with IFN-α and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01–0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-α therapy and required imatinib, patients who achieved CMR had excellent long-term outcome We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-α) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4–212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7–40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase–polymerase chain reaction [“complete” molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4–10) years, while 2 continue with IFN-α and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01–0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-α therapy and required imatinib, patients who achieved CMR had excellent long-term outcome (en)
Title	Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia (en)
skos:prefLabel	Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia (en)
skos:notation	RIV/00098892:_____/12:#0000333!RIV13-MZ0-00098892
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kuba, Adam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Olomouc
http://linked.open...dnocenehoVysledku	156680
http://linked.open...ai/riv/idVysledku	RIV/00098892:_____/12:#0000333
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	interferon-alpha, chronic myeloid leukemia, operational cure (en)
http://linked.open.../riv/klicoveSlovo	chronic myeloid leukemia interferon-alpha operational cure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C53CF4271355]
http://linked.open...i/riv/nazevZdroje	Journal of Interferon & Cytokine Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Faber, Edgar Kuba, Adam
issn	1079-9907
number of pages	5 (xsd:int)

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