About: Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein     Goto   Sponge   NotDistinct   Permalink

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Description
  • Microphthalmia transkripční faktor (MITF) má rozhodující vliv ve vývoji melanocytových linií a u maligních melanomů je nadexprimovaný. Protein E1A je známý mimo jiné antitumorovou aktivitou, která je spojená s jeho transkripčně represorovou funkcí a schopností indukovat apoptózu a má potenciálně antimelanomové účinky. Testovali jsme přímou represi MITF-promotoru, specifického pro melanocyty, pomocí E1A a jeho mutant. Zjistili jsme, že N-koncová oblast a konzervovaná doména 1 jsou nezbytné pro tuto represi. (cs)
  • Micropthtalmia transcription faktor (MITF) is crucial for the development of the melanocyte lineage and is overexpressed in malignant melanomas. The E1A protein is known to also exert an antitumor activity, which is associated with its transcription repression function and the ability to induce apoptosis and is a potential antimelanoma agent. We tested a direct repression of the melanocyte-specific MITF promoter by E1A and its mutants and we found that the extreme N-terminus and conserved region 1 are required for repression.
  • Micropthtalmia transcription faktor (MITF) is crucial for the development of the melanocyte lineage and is overexpressed in malignant melanomas. The E1A protein is known to also exert an antitumor activity, which is associated with its transcription repression function and the ability to induce apoptosis and is a potential antimelanoma agent. We tested a direct repression of the melanocyte-specific MITF promoter by E1A and its mutants and we found that the extreme N-terminus and conserved region 1 are required for repression. (en)
Title
  • Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein
  • Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein (en)
  • Represe melanocytově specifického promotoru microphthalmia-asociovaného transkripčního faktoru adenovirovým oncoproteinem E1A 12S (cs)
skos:prefLabel
  • Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein
  • Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein (en)
  • Represe melanocytově specifického promotoru microphthalmia-asociovaného transkripčního faktoru adenovirovým oncoproteinem E1A 12S (cs)
skos:notation
  • RIV/00064211:_____/04:00011449!RIV/2005/MZ0/L10005/N
http://linked.open.../vavai/riv/strany
  • 159-166
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ00000064211)
http://linked.open...iv/cisloPeriodika
  • 50
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 584357
http://linked.open...ai/riv/idVysledku
  • RIV/00064211:_____/04:00011449
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • E1A;microphthalmia;MITF;melanoma;repression;0 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [A721CF32B818]
http://linked.open...i/riv/nazevZdroje
  • FOLIA BIOLOGICA
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • neuveden
http://linked.open...iv/tvurceVysledku
  • Vachtenheim, Jiří
  • Drdová, Blanka
http://linked.open...n/vavai/riv/zamer
issn
  • 0015-5500
number of pages
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