About: Microphthalmia Transcription Factor: a Specific Marker for Malignant Melanoma     Goto   Sponge   NotDistinct   Permalink

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Description
  • The transcription faktor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstrem transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.
  • The transcription faktor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstrem transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors. (en)
  • Transkripční faktor microphthalmia (MITF) je nutný pro vývoj normálních melanocytů během embryonálního vývoje a pro expresi markerů specifických pro pigmentové buňky. Tyto markery jsou transkripční cíle faktoru MITF. MITF se též zdá být klíčový pro přežívání melanomových buněk. Speciálním obsahem tohoto přehledového článku je využitelnost MITF jako markeru maligního melanomu. Melanocytově-specifická forma MITF se zdá být unikátní molekulou v diferenciální diagnose melanocytových nádorů. (cs)
Title
  • Microphthalmia Transcription Factor: a Specific Marker for Malignant Melanoma
  • Microphthalmia transkripční faktor: specifický marker maligních melanomů (cs)
  • Microphthalmia Transcription Factor: a Specific Marker for Malignant Melanoma (en)
skos:prefLabel
  • Microphthalmia Transcription Factor: a Specific Marker for Malignant Melanoma
  • Microphthalmia transkripční faktor: specifický marker maligních melanomů (cs)
  • Microphthalmia Transcription Factor: a Specific Marker for Malignant Melanoma (en)
skos:notation
  • RIV/00064211:_____/04:00011447!RIV/2005/MZ0/L10005/N
http://linked.open.../vavai/riv/strany
  • 318-324
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR8026)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 573498
http://linked.open...ai/riv/idVysledku
  • RIV/00064211:_____/04:00011447
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MITF;Melanoma;melanocyte;Microphthalmia;Transcription; (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [34532D1B64ED]
http://linked.open...i/riv/nazevZdroje
  • Prague Medical report
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • neuveden
http://linked.open...iv/tvurceVysledku
  • Borovanský, Jan
  • Vachtenheim, Jiří
issn
  • 1214-6994
number of pages
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