About: Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome     Goto   Sponge   NotDistinct   Permalink

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Description
  • Introduction: Myasthenia gravis is an autoimmune disease marked by neuromuscular transmission failure at the neuromuscular junction. Castleman disease is a rare lymphoproliferative disease characterized by non-cancerous angiofolicular hyperplasia of lymphatic tissue. Methods and results: We describe a young man with rapid, successive manifestations of myasthenia gravis, a solitary form of Castleman disease, pemphigus vulgaris, and anti-phospholipid syndrome, which resulted in 2 ischemic cerebrovascular events that caused a severe central neurological deficit. Discussion: We were unable to find a similar case in the literature, but we hypothesize that the temporal concidence of these clinical entities may be related to a common immunological pathway, such as B-cell activation. Therefore, we treated the patient with an immunosuppressant and anticoagulant treatment, as well as rituximab, a monoclonal antibody therapy against CD20+. Muscle Nerve 47:447-451, 2013
  • Introduction: Myasthenia gravis is an autoimmune disease marked by neuromuscular transmission failure at the neuromuscular junction. Castleman disease is a rare lymphoproliferative disease characterized by non-cancerous angiofolicular hyperplasia of lymphatic tissue. Methods and results: We describe a young man with rapid, successive manifestations of myasthenia gravis, a solitary form of Castleman disease, pemphigus vulgaris, and anti-phospholipid syndrome, which resulted in 2 ischemic cerebrovascular events that caused a severe central neurological deficit. Discussion: We were unable to find a similar case in the literature, but we hypothesize that the temporal concidence of these clinical entities may be related to a common immunological pathway, such as B-cell activation. Therefore, we treated the patient with an immunosuppressant and anticoagulant treatment, as well as rituximab, a monoclonal antibody therapy against CD20+. Muscle Nerve 47:447-451, 2013 (en)
Title
  • Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome
  • Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome (en)
skos:prefLabel
  • Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome
  • Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome (en)
skos:notation
  • RIV/00064203:_____/13:10188935!RIV14-MZ0-00064203
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, S, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 90287
http://linked.open...ai/riv/idVysledku
  • RIV/00064203:_____/13:10188935
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • pemphigus vulgaris; myasthenia gravis; interleukin-6; Castleman disease; anti-phospholipid syndrome (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [193D1DE05E04]
http://linked.open...i/riv/nazevZdroje
  • Muscle and Nerve
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 47
http://linked.open...iv/tvurceVysledku
  • Ehler, Edvard
  • Schützner, Jan
  • Piťha, Jiří
  • Jakubíková, Michala
  • Latta, Jan
http://linked.open...ain/vavai/riv/wos
  • 000315401500021
http://linked.open...n/vavai/riv/zamer
issn
  • 0148-639X
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/mus.23657
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