Description
| - From the study design, 16,000 people were to be followed for approximately 5.5 years. However, the trial was stopped prematurely because of regulatory concerns after a mean of 162 days without consideration of the accrued data. In the TZD arm, the cardiovascular outcome occurred in five participants (0.9%) in the placebo groups and three participants (0.4%) in the TZD groups (two allocated to pioglitazone, one to rosiglitazone). In the vitamin D arm, the primary outcome occurred in three participants (0.5%) in the placebo group and in two participants (0.3%) receiving vitamin D. Adverse events were comparable in all groups.
- From the study design, 16,000 people were to be followed for approximately 5.5 years. However, the trial was stopped prematurely because of regulatory concerns after a mean of 162 days without consideration of the accrued data. In the TZD arm, the cardiovascular outcome occurred in five participants (0.9%) in the placebo groups and three participants (0.4%) in the TZD groups (two allocated to pioglitazone, one to rosiglitazone). In the vitamin D arm, the primary outcome occurred in three participants (0.5%) in the placebo group and in two participants (0.3%) receiving vitamin D. Adverse events were comparable in all groups. (en)
|
http://linked.open...iv/tvurceVysledku
| - Diaz, R.
- Kvapil, Milan
- Yusuf, S.
- Pogue, J.
- Afzal, R.
- Ariani, M.
- Arsenault, J.
- Barzilay, J.
- Bilazarian, S.
- Bommer, W.
- Bosch, J.
- Brautigam, D.
- Burke, M.
- Castelli, J.
- Cushman, W.
- Dagenais, G.
- Feinglos, M.
- Forbes, B.
- Force, R.
- Gerstein, H.
- Giddings, S.
- Gillespie, E.
- Hamaty, M.
- Hardman, C.
- Haywood, L.
- Ho, L.
- Hollander, P.
- Holman, R.
- Joldersma, L.
- Karl, D.
- Kashyap, M.
- Linz, P.
- Lui, S.
- MacRae, L.
- Marshall, T.
- Ng, J.
- Nicol, P.
- Nyenwe, E.
- Probstfield, J.
- Punthakee, Z.
- Raghavan, V.
- Ramachandran, A.
- Reznick, DeMarco, Y
- Richardson, L.
- Riddle, M.
- Roberts, S.
- Ryden, L.
- Solbrig, R.
- Sperl, J.
- Stevens, C.
- Sweeney, M.
- Tosta, F.
- Wasala, L.
- Webster, J.
- Whate, A.
- White, J.
- Wu, P.
- Wyne, K.
- Yuan, F.
- Zinman, B.
- Zotova, E.
|