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Description
| - In this study, the results of the proteomic analysis of plasma samples of stable angina patients are presented. Background: Plasma samples from 44 patients were analysed in two groups: (A) a control group of 22 patients without significant coronary artery disease and (B) 22 patients admitted with stable angina pectoris. Methods: During coronary angiography, plasma samples were collected and further analysed using two-dimensional gel electrophoresis, image analysis and mass spectrometry. Results: Five spots were found with significantly increased or decreased normalised volumes resulting from either a change in the amount of protein or changes in posttranslational modifications. Spots containing serum amyloid A protein and fibrinogen gamma chains displayed increased normalised volumes, and spots containing apoliprotein A-1 and pigment epithelium derived factor showed decreased normalised volumes. Conclusions: Almost identical proteomic profiles of the stable angina pectoris group compared with the control group corresponded well with clinical results comparing stable patients with the general population.
- In this study, the results of the proteomic analysis of plasma samples of stable angina patients are presented. Background: Plasma samples from 44 patients were analysed in two groups: (A) a control group of 22 patients without significant coronary artery disease and (B) 22 patients admitted with stable angina pectoris. Methods: During coronary angiography, plasma samples were collected and further analysed using two-dimensional gel electrophoresis, image analysis and mass spectrometry. Results: Five spots were found with significantly increased or decreased normalised volumes resulting from either a change in the amount of protein or changes in posttranslational modifications. Spots containing serum amyloid A protein and fibrinogen gamma chains displayed increased normalised volumes, and spots containing apoliprotein A-1 and pigment epithelium derived factor showed decreased normalised volumes. Conclusions: Almost identical proteomic profiles of the stable angina pectoris group compared with the control group corresponded well with clinical results comparing stable patients with the general population. (en)
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Title
| - Proteomic analysis of the plasma samples of patients with stable angina pectoris
- Proteomic analysis of the plasma samples of patients with stable angina pectoris (en)
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skos:prefLabel
| - Proteomic analysis of the plasma samples of patients with stable angina pectoris
- Proteomic analysis of the plasma samples of patients with stable angina pectoris (en)
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skos:notation
| - RIV/00064203:_____/12:8391!RIV13-MZ0-00064203
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(KAN200670701), P(NS10633), Z(MZ0FNM2005), Z(MZ0UHKT2005)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064203:_____/12:8391
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Angina pectoris; Mass spectrometry; Proteomic analysis (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hájek, Petr
- Malý, Martin
- Veselka, Josef
- Suttnar, J.
- Dyr, J. A.
- Kotlin, R.
- Majek, P.
- Oravec, Milan
- Reicheltova, Z.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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