About: The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients

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About: The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s00431-012-1833-2
Description	We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Na ratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedside method as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis of bicarbonate. We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Na ratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedside method as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis of bicarbonate. (en)
Title	The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients (en)
skos:prefLabel	The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients (en)
skos:notation	RIV/00064203:_____/12:8251!RIV13-MZ0-00064203
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Horáčková, Miroslava Schück, Otto Matoušovic, Karel Charvát, Jiří Havlín, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	176419
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/12:8251
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	anion gap (en)
http://linked.open.../riv/klicoveSlovo	anion gap
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[34A504EEDD10]
http://linked.open...i/riv/nazevZdroje	European Journal of Pediatrics
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	171
http://linked.open...iv/tvurceVysledku	Schück, Otto Horáčková, Miroslava Charvát, Jiří Matoušovic, Karel Havlín, Jan
http://linked.open...ain/vavai/riv/wos	000310810700023
issn	0340-6199
number of pages	1 (xsd:int)

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