About: Parkinson's disease, L-DOPA, and endogenous morphine: A revisit

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/22847214
Description	Clinical observations stemming from widespread employment of restorative L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for management of dyskinesia in Parkinson's Disease (PD) patients implicate a regulatory role for endogenous morphine in central nervous system dopamine neurotransmission. Reciprocally, it appears that restorative L-DOPA administration has provided us with a compelling in vivo pharmacological model for targeting peripheral sites involved in endogenous morphine expression in human subjects. The biological activities underlying endogenous morphine expression and its interaction with its major precursor dopamine strongly suggest that endogenous morphine systems are reciprocally dysregulated in PD. These critical issues are examined from historical and current perspectives within our short review. Clinical observations stemming from widespread employment of restorative L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for management of dyskinesia in Parkinson's Disease (PD) patients implicate a regulatory role for endogenous morphine in central nervous system dopamine neurotransmission. Reciprocally, it appears that restorative L-DOPA administration has provided us with a compelling in vivo pharmacological model for targeting peripheral sites involved in endogenous morphine expression in human subjects. The biological activities underlying endogenous morphine expression and its interaction with its major precursor dopamine strongly suggest that endogenous morphine systems are reciprocally dysregulated in PD. These critical issues are examined from historical and current perspectives within our short review. (en)
Title	Parkinson's disease, L-DOPA, and endogenous morphine: A revisit Parkinson's disease, L-DOPA, and endogenous morphine: A revisit (en)
skos:prefLabel	Parkinson's disease, L-DOPA, and endogenous morphine: A revisit Parkinson's disease, L-DOPA, and endogenous morphine: A revisit (en)
skos:notation	RIV/00064203:_____/12:8211!RIV13-MZ0-00064203
http://linked.open...avai/riv/aktivita	I N
http://linked.open...avai/riv/aktivity	I, N
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kuželová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	157852
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/12:8211
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dopamine; L-DOPA; Parkinson's disease; morphine; tetrahydropapaveroline; nitric-oxide release; white blood-cells; cocaine-evoked release; ventral tegmental area; tetrahydroisoquinoline alkaloids; rat-brain; in-vivo; opiate alkaloids; invertebrate ganglia; synthesize morphine (en)
http://linked.open.../riv/klicoveSlovo	L-DOPA Parkinson's disease white blood-cells dopamine in-vivo morphine cocaine-evoked release invertebrate ganglia nitric-oxide release opiate alkaloids rat-brain synthesize morphine tetrahydroisoquinoline alkaloids tetrahydropapaveroline ventral tegmental area
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[0E3A95273F04]
http://linked.open...i/riv/nazevZdroje	Medical Science Monitor
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Kuželová, Hana Kream, R. M. Stefano, GB Ptacek, R. Esch, T. Kralickova, M. Mantione, KJ
http://linked.open...ain/vavai/riv/wos	000308604800025
issn	1234-1010
number of pages	5 (xsd:int)

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