About: Selective Increase in Blood Dendritic Cell Antigen-3-Positive Dendritic Cells in Bronchoalveolar Lavage Fluid in Allergic Patients

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About: Selective Increase in Blood Dendritic Cell Antigen-3-Positive Dendritic Cells in Bronchoalveolar Lavage Fluid in Allergic Patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1111/j.1365-3083.2011.02649.x
Description	Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and in controls. Plasmacytoid and four distinct subsets of myeloid DCs [characterized by the expression of blood dendritic cell antigen (BDCA)-1+ and -3+ and CD16 positivity or negativity] were detected in both tested compartments. We further evaluated the expression of C-type lectins [mannose receptor (MR), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and dendritic and epithelial cells (DEC)-205] relevant to the pathogenesis of asthma. Interestingly, we found a selective increase in the frequency of myeloid DC-expressing BDCA-3 and MR particularly in BALF from allergic patients. Specific and highly statistically significant increase in BDCA-3+ and/or MR+ DCs brings a novel characteristic to BAL analysis in allergic patients. Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and in controls. Plasmacytoid and four distinct subsets of myeloid DCs [characterized by the expression of blood dendritic cell antigen (BDCA)-1+ and -3+ and CD16 positivity or negativity] were detected in both tested compartments. We further evaluated the expression of C-type lectins [mannose receptor (MR), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and dendritic and epithelial cells (DEC)-205] relevant to the pathogenesis of asthma. Interestingly, we found a selective increase in the frequency of myeloid DC-expressing BDCA-3 and MR particularly in BALF from allergic patients. Specific and highly statistically significant increase in BDCA-3+ and/or MR+ DCs brings a novel characteristic to BAL analysis in allergic patients. (en)
Title	Selective Increase in Blood Dendritic Cell Antigen-3-Positive Dendritic Cells in Bronchoalveolar Lavage Fluid in Allergic Patients Selective Increase in Blood Dendritic Cell Antigen-3-Positive Dendritic Cells in Bronchoalveolar Lavage Fluid in Allergic Patients (en)
skos:prefLabel	Selective Increase in Blood Dendritic Cell Antigen-3-Positive Dendritic Cells in Bronchoalveolar Lavage Fluid in Allergic Patients Selective Increase in Blood Dendritic Cell Antigen-3-Positive Dendritic Cells in Bronchoalveolar Lavage Fluid in Allergic Patients (en)
skos:notation	RIV/00064203:_____/12:8063!RIV13-MZ0-00064203
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620812), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Špíšek, Radek Pohunek, Petr Šedivá, Anna Rožková, Daniela Skalická, Veronika Budinský, Vít Vernerová, Eva Zentsová, Irena Kayserová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	167321
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/12:8063
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antigen-presenting cells; human lung; airway inflammation; peripheral-blood; mannose receptor; mite allergen; dc-sign; subsets; expression; differentiation (en)
http://linked.open.../riv/klicoveSlovo	expression airway inflammation antigen-presenting cells dc-sign human lung mannose receptor mite allergen subsets differentiation peripheral-blood
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[CC4D1326716A]
http://linked.open...i/riv/nazevZdroje	Scandinavian Journal of Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Pohunek, Petr Šedivá, Anna Kopecká, Jana Špíšek, Radek Rožková, Daniela Skalická, Veronika Vernerová, Eva Budinský, Vít Kayserová, Jana Zentsová, Irena
http://linked.open...ain/vavai/riv/wos	000300499200007
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	0300-9475
number of pages	9 (xsd:int)

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