About: In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus

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About: In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1093/jac/dkr108
Description	Objectives: In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus. Methods: The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs). Results: Synergistic activity was observed for combinations of baicalin with oxytetracycline or tetracycline against 4 of 10 strains tested, whereas the baicalin/oxytetracycline combination possessed the strongest synergistic effect. Conclusions: Baicalin acts synergistically with oxytetracycline and tetracycline, enhancing its antimicrobial activity against S. aureus, including methicillin- and tetracycline-resistant strains. Objectives: In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus. Methods: The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs). Results: Synergistic activity was observed for combinations of baicalin with oxytetracycline or tetracycline against 4 of 10 strains tested, whereas the baicalin/oxytetracycline combination possessed the strongest synergistic effect. Conclusions: Baicalin acts synergistically with oxytetracycline and tetracycline, enhancing its antimicrobial activity against S. aureus, including methicillin- and tetracycline-resistant strains. (en)
Title	In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus (en)
skos:prefLabel	In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus (en)
skos:notation	RIV/00064203:_____/11:8928!RIV13-MZ0-00064203
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GD525/08/H060), Z(MSM6046070901)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Urban, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	204049
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/11:8928
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antimicrobial agents, flavonoid, staphylococci, synergy (en)
http://linked.open.../riv/klicoveSlovo	antimicrobial agents flavonoid staphylococci synergy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[91474862B00A]
http://linked.open...i/riv/nazevZdroje	Journal of Antimicrobial Chemotherapy
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Synbiotics and plant extracts in human and animal nutrition
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	66
http://linked.open...iv/tvurceVysledku	Kokoška, L. Urban, Jan Vadlejch, J. Leuner, O. Nový, P.
http://linked.open...ain/vavai/riv/wos	000290587800018
http://linked.open...n/vavai/riv/zamer	Setrvalé zemědělství, kvalita zemědělské produkce, krajinné a přírodní zdroje.
issn	0305-7453
number of pages	3 (xsd:int)

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