| Attributes | Values |
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| rdf:type
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| rdfs:seeAlso
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| Description
| - Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0.0001) and urinary alpha 1-microglobulin (r = 0.82, P = 0.0002) were found in patients with OU. Conclusion: Children with OU have higher urinary TGF-beta 1 than children with NOU. Urinary TGF-beta 1 may be a useful non-invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF-beta 1 with markers of renal tissue damage in patients with OU was found.
- Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0.0001) and urinary alpha 1-microglobulin (r = 0.82, P = 0.0002) were found in patients with OU. Conclusion: Children with OU have higher urinary TGF-beta 1 than children with NOU. Urinary TGF-beta 1 may be a useful non-invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF-beta 1 with markers of renal tissue damage in patients with OU was found. (en)
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| Title
| - Urinary transforming growth factor-beta 1 in children with obstructive uropathy
- Urinary transforming growth factor-beta 1 in children with obstructive uropathy (en)
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| skos:prefLabel
| - Urinary transforming growth factor-beta 1 in children with obstructive uropathy
- Urinary transforming growth factor-beta 1 in children with obstructive uropathy (en)
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| skos:notation
| - RIV/00064203:_____/11:7032!RIV12-MZ0-00064203
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00064203:_____/11:7032
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - alpha 1-microglobulin; microalbuminuria; obstructive uropathy; proteinuria; transforming growth factor-beta 1; ureteropelvic junction obstruction; epidermal-growth-factor; tract obstruction; congenital hydronephrosis; transforming-growth-factor-beta(1); nephropathy; kidney; system (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - AU - Australské společenství
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bronský, Jiří
- Janda, Jan
- Seeman, Tomáš
- Bláhová, Květa
- Matoušovic, Karel
- Zieg, Jakub
- Dvořáková, Hana Marie
- Pechová, Marta
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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