About: Assessment of problematic severe asthma in children

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/21030450
Description	Assessment of problematic severe asthma in children should be performed in a stepwise manner to ensure an optimal approach. A four-step assessment scheme is proposed. First, a full diagnostic work-up is performed to exclude other diseases which mimic asthma. Secondly, a multi-disciplinary assessment is performed to identify issues that may need attention, including comorbidities. Thirdly, the pattern of inflammation is assessed, and finally steroid responsiveness is documented. Based upon these four steps an optimal individualised treatment plan is developed. In this article the many gaps in our current knowledge in all these steps are highlighted, and recommendations for current clinical practice and future research are made. The lack of good data and the heterogeneity of problematic severe asthma still limit our ability to optimise the management on an individual basis in this small, but challenging group of patients. Assessment of problematic severe asthma in children should be performed in a stepwise manner to ensure an optimal approach. A four-step assessment scheme is proposed. First, a full diagnostic work-up is performed to exclude other diseases which mimic asthma. Secondly, a multi-disciplinary assessment is performed to identify issues that may need attention, including comorbidities. Thirdly, the pattern of inflammation is assessed, and finally steroid responsiveness is documented. Based upon these four steps an optimal individualised treatment plan is developed. In this article the many gaps in our current knowledge in all these steps are highlighted, and recommendations for current clinical practice and future research are made. The lack of good data and the heterogeneity of problematic severe asthma still limit our ability to optimise the management on an individual basis in this small, but challenging group of patients. (en)
Title	Assessment of problematic severe asthma in children Assessment of problematic severe asthma in children (en)
skos:prefLabel	Assessment of problematic severe asthma in children Assessment of problematic severe asthma in children (en)
skos:notation	RIV/00064203:_____/11:6956!RIV12-MZ0-00064203
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pohunek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	187282
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/11:6956
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Asthma; child; diagnostics; severe; quality-of-life; exhaled nitric-oxide; exercise-induced bronchoconstriction; randomized controlled-trial; to-treat asthma; lung-function; difficult asthma; airway hyperresponsiveness; sputum induction; childhood asthma (en)
http://linked.open.../riv/klicoveSlovo	Asthma airway hyperresponsiveness childhood asthma difficult asthma exercise-induced bronchoconstriction exhaled nitric-oxide lung-function quality-of-life severe sputum induction to-treat asthma diagnostics randomized controlled-trial child - threat - divorce - domestic violence - abandonment - adoption
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[56E3970FB011]
http://linked.open...i/riv/nazevZdroje	European Respiratory Journal
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Baraldi, E. Barbato, A. Bush, A. Carlsen, KCL Carlsen, KH De Jongste, JC Hedlin, G. Malmstrom, K. Middelveld, RJM Pohunek, Petr Pedersen, S. Pedroletti, C. Piacentini, G. L. Wennergren, G. de Benedictis, FM
http://linked.open...ain/vavai/riv/wos	000286730400030
issn	0903-1936
number of pages	9 (xsd:int)

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