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  • Translocations involving the mixed lineage leukemia (MLL) gene, localized at 11q23, frequently occur in pediatric acute myeloid leukemia (AML). We used microarrays to generate gene expression profiles of 245 pediatric AML cases, including 53 MLL-rearranged cases. Overrexpression of the BRE gene is predominantly found in MLL-rearranged AML with t(9;11)(p22;q23). Although further investigation for the role of BRE in leukemogenesis and outcome is warranted, high BRE expression is an independent prognostic factor for pRFS in pediatric AML.
  • Translocations involving the mixed lineage leukemia (MLL) gene, localized at 11q23, frequently occur in pediatric acute myeloid leukemia (AML). We used microarrays to generate gene expression profiles of 245 pediatric AML cases, including 53 MLL-rearranged cases. Overrexpression of the BRE gene is predominantly found in MLL-rearranged AML with t(9;11)(p22;q23). Although further investigation for the role of BRE in leukemogenesis and outcome is warranted, high BRE expression is an independent prognostic factor for pRFS in pediatric AML. (en)
Title
  • High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome
  • High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome (en)
skos:prefLabel
  • High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome
  • High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome (en)
skos:notation
  • RIV/00064203:_____/10:6373!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 261497
http://linked.open...ai/riv/idVysledku
  • RIV/00064203:_____/10:6373
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MLL; BRE; pediatric AML (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [5D37CA461C99]
http://linked.open...i/riv/nazevZdroje
  • Leukemia
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 24
http://linked.open...iv/tvurceVysledku
  • Balgobind, BV
  • Baruchel, A.
  • Creutzig, U.
  • Hollink, IHIM
  • Kaspers, GJL
  • Pieters, R.
  • Reinhardt, D.
  • Starý, Jan
  • Zwaan, CM
  • de Bont, ESJM
  • van den Heuvel-Eibrink, MM
  • Marschalek, R.
  • Meyer, C.
  • den Boer, M. L.
  • de Haas, V.
  • Arentsen-Peters, TJCM
http://linked.open...ain/vavai/riv/wos
  • 000285380900009
issn
  • 0887-6924
number of pages
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