About: Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objective. To determine the impact of physiologic changes of pregnancy on pharmacokinetics of chemotherapeutic agents. Design. A preclinical and a clinical case-control trial. Setting. Institute of Primate Research Nairobi and collaborating hospitals in Belgium, the Netherlands and Czech Republic. Population. Pregnant and nonpregnant women and baboons receiving chemotherapy. Methods. Chemotherapy pharmacokinetics was compared between the pregnant and nonpregnant state. Standard-dosed chemotherapy regimens were administered in pregnant and nonpregnant baboons/women, followed by serial blood samplings. Drug plasma levels were determined using high performance liquid chromatography and atomic absorption spectrometry. Main outcome measures. Area under the curve (AUC), maximal plasma concentration, terminal elimination half-life, clearance and distribution volume of each drug in pregnant and nonpregnant state. Objective. To determine the impact of physiologic changes of pregnancy on pharmacokinetics of chemotherapeutic agents. Design. A preclinical and a clinical case-control trial. Setting. Institute of Primate Research Nairobi and collaborating hospitals in Belgium, the Netherlands and Czech Republic. Population. Pregnant and nonpregnant women and baboons receiving chemotherapy. Methods. Chemotherapy pharmacokinetics was compared between the pregnant and nonpregnant state. Standard-dosed chemotherapy regimens were administered in pregnant and nonpregnant baboons/women, followed by serial blood samplings. Drug plasma levels were determined using high performance liquid chromatography and atomic absorption spectrometry. Main outcome measures. Area under the curve (AUC), maximal plasma concentration, terminal elimination half-life, clearance and distribution volume of each drug in pregnant and nonpregnant state. (en)
Title	Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study (en)
skos:prefLabel	Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study (en)
skos:notation	RIV/00064203:_____/10:6342!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita	O
http://linked.open...avai/riv/aktivity	O
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Halaška, Michael Rob, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	278710
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/10:6342
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chemotherapy; pharmacokinetics; pregnancy; baboon; renal-function; paclitaxel; tissues; formula (en)
http://linked.open.../riv/klicoveSlovo	formula pregnancy pharmacokinetics Chemotherapy tissues baboon paclitaxel renal-function
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[74014C8E25CB]
http://linked.open...i/riv/nazevZdroje	Acta Obstetricia et Gynecologica Scandinavica
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Halaška, Michael Rob, Lukáš Amant, F. Heyns, L. Van Calsteren, K. de Bruijn, E. Delforge, M. Chai, D. Noens, L. Ottevanger, N. Renard, V. Van Bree, R. Verbesselt, R. Witteveen, E. de Hoon, J.
http://linked.open...ain/vavai/riv/wos	000282963700016
issn	0001-6349
number of pages	8 (xsd:int)

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