About: Tumor Risk in Disorders of Sex Development

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Certain patients with disorders of sex development (DSD), who bear Y chromosome material in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT), which arise from early fetal germ cells. DSD gonads frequently harbor immature germ cells which express early fetal germ cell markers. Some of them (e.g. OCT3/4 and NANOG) seem to be of pathogenetic relevance in GCT development providing cells with the ability of pluripotency, proliferation and apoptosis suppression. Also TSPY (testis-specific protein Y-encoded), the main candidate for the so-called gonadoblastoma locus on Y chromosome, is over-expressed in germ cells of DSD patients and possibly contributes to their survival and proliferation. Nowadays, the use of immunohistochemical methods is highly relevant in identifying DSD gonads at risk. The risk for GCT development varies. While the prevalence of GCT is 15% in patients with partial androgen insensitivity, it may reach more than 30% in patients with gonadal dys Certain patients with disorders of sex development (DSD), who bear Y chromosome material in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT), which arise from early fetal germ cells. DSD gonads frequently harbor immature germ cells which express early fetal germ cell markers. Some of them (e.g. OCT3/4 and NANOG) seem to be of pathogenetic relevance in GCT development providing cells with the ability of pluripotency, proliferation and apoptosis suppression. Also TSPY (testis-specific protein Y-encoded), the main candidate for the so-called gonadoblastoma locus on Y chromosome, is over-expressed in germ cells of DSD patients and possibly contributes to their survival and proliferation. Nowadays, the use of immunohistochemical methods is highly relevant in identifying DSD gonads at risk. The risk for GCT development varies. While the prevalence of GCT is 15% in patients with partial androgen insensitivity, it may reach more than 30% in patients with gonadal dys (en)
Title	Tumor Risk in Disorders of Sex Development Tumor Risk in Disorders of Sex Development (en)
skos:prefLabel	Tumor Risk in Disorders of Sex Development Tumor Risk in Disorders of Sex Development (en)
skos:notation	RIV/00064203:_____/10:6315!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	4-5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lebl, Jan Pleskačová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	293733
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/10:6315
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	disorders of sex development; germ cell tumors; pathogenesis; risk; germ-cell tumors; carcinoma-in-situ; testicular dysgenesis syndrome; c-kit; development dsd; environmental aspects; expression; gene; differentiation; gonads (en)
http://linked.open.../riv/klicoveSlovo	germ-cell tumors expression gene pathogenesis risk gonads environmental aspects carcinoma-in-situ development dsd testicular dysgenesis syndrome c-kit differentiation disorders of sex development germ cell tumors
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[BEEFC76F75F1]
http://linked.open...i/riv/nazevZdroje	Sexual Development
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Lebl, Jan Cools, M. Oosterhuis, JW Pleskačová, Jana Wolffenbuttel, K. P. Looijenga, LH Drop, SL Faradz, S. M. Hersmus, R. Setyawati, BA
http://linked.open...ain/vavai/riv/wos	000281664100009
issn	1661-5425
number of pages	11 (xsd:int)

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