About: The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Previous studies found no association of CTLA4 (cytotoxic T-lymphocyte antigen 4) with Crohn's disease (CD). In the Czech population 6 SNPs were investigated in 333 patients with CD and 482 healthy controls. No associations with CD were found for the tested CTLA4 variants. After stratification for the genetic risk conferred by the variants in the NOD2 (rs5743293) or the IL23R (rs11209026), a significant negative association emerged for the minor alleles of SNPs rs3087243, rs11571302, rs11571297. In the strata defined by presence minor alleles at the NOD2 rs5743293, rs3087243 conffered risk OR 0.4, 95%CI 0.2 -1.0, or IL23R rs11209026, rs3087243 coneferred risk OR 0.2, 95% CI 0.1 -0.7. We observed this effect also for the haplotype consisting of minor alleles of the 3 tightly linked SNPs. This haplotype was associated with the younger age at diagnosis (OR 1.5, 95%CI 1.1 -2.1). A protective effect of a CTLA4 haplotype may point towards the biological relevance of CTLA4 in the pathogenesis of CD. Previous studies found no association of CTLA4 (cytotoxic T-lymphocyte antigen 4) with Crohn's disease (CD). In the Czech population 6 SNPs were investigated in 333 patients with CD and 482 healthy controls. No associations with CD were found for the tested CTLA4 variants. After stratification for the genetic risk conferred by the variants in the NOD2 (rs5743293) or the IL23R (rs11209026), a significant negative association emerged for the minor alleles of SNPs rs3087243, rs11571302, rs11571297. In the strata defined by presence minor alleles at the NOD2 rs5743293, rs3087243 conffered risk OR 0.4, 95%CI 0.2 -1.0, or IL23R rs11209026, rs3087243 coneferred risk OR 0.2, 95% CI 0.1 -0.7. We observed this effect also for the haplotype consisting of minor alleles of the 3 tightly linked SNPs. This haplotype was associated with the younger age at diagnosis (OR 1.5, 95%CI 1.1 -2.1). A protective effect of a CTLA4 haplotype may point towards the biological relevance of CTLA4 in the pathogenesis of CD. (en)
Title	The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease (en)
skos:prefLabel	The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease (en)
skos:notation	RIV/00064203:_____/10:6280!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NR9219), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	91
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Cinek, Ondřej Bronský, Jiří Nevoral, Jiří Dušátková, Petra Hradský, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	252488
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/10:6280
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CTLA4, Crohnova choroba, genetická asociace; CTLA4, Crohn's disease, genetic association (en)
http://linked.open.../riv/klicoveSlovo	Crohn's disease CTLA4 Crohnova choroba genetic association genetická asociace
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[AB909559DDBF]
http://linked.open...i/riv/nazevZdroje	BMC Medical Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	The effect of genotype/fenotype pattern on the disease course and on the therapeutic response in patients with ulcerative colitis and Crohn´s disease (IBD)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Bronský, Jiří Cinek, Ondřej Nevoral, Jiří Dušátková, Petra Hradský, Ondřej Vitek, Libor Lenicek, Martin Lukas, Milan Ženíšková, Ivana
http://linked.open...ain/vavai/riv/wos	000279920800002
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	1471-2350
number of pages	9 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software