About: Quantification of Extracellular DNA Using Hypermethylated RASSF1A, SRY, and GLO Sequences-Evaluation of Diagnostic Possibilities for Predicting Placental Insufficiency

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About: Quantification of Extracellular DNA Using Hypermethylated RASSF1A, SRY, and GLO Sequences-Evaluation of Diagnostic Possibilities for Predicting Placental Insufficiency Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study evaluated quantification of fetal extracellular DNA in maternal plasma for differentiation between cases at risk of onset of placental-insufficiency-related complications and normal pregnancies. Using real-time polymerase chain reaction, fetal (sex-determining region Y [SRY] and hypermethylated RASSF1A sequence) and total (beta-globin [GLO] gene) extracellular DNA was examined in 70 normal pregnancies, 18 at risk of placental-insufficiency-related pregnancy complications, 24 preeclampsia with or without (w or w/o) intrauterine growth retardation (IUGR) (median 34.0 week), and 11 IUGR (median 28.5 week). IUGR was diagnosed when estimated fetal weight was below the 10th percentile for evaluated gestational age. These data indicate that fetal and total extracellular DNA concentrations can be significantly elevated in plasma of patients who later developed placental-insufficiency-related pregnancy complications. This study evaluated quantification of fetal extracellular DNA in maternal plasma for differentiation between cases at risk of onset of placental-insufficiency-related complications and normal pregnancies. Using real-time polymerase chain reaction, fetal (sex-determining region Y [SRY] and hypermethylated RASSF1A sequence) and total (beta-globin [GLO] gene) extracellular DNA was examined in 70 normal pregnancies, 18 at risk of placental-insufficiency-related pregnancy complications, 24 preeclampsia with or without (w or w/o) intrauterine growth retardation (IUGR) (median 34.0 week), and 11 IUGR (median 28.5 week). IUGR was diagnosed when estimated fetal weight was below the 10th percentile for evaluated gestational age. These data indicate that fetal and total extracellular DNA concentrations can be significantly elevated in plasma of patients who later developed placental-insufficiency-related pregnancy complications. (en)
Title	Quantification of Extracellular DNA Using Hypermethylated RASSF1A, SRY, and GLO Sequences-Evaluation of Diagnostic Possibilities for Predicting Placental Insufficiency Quantification of Extracellular DNA Using Hypermethylated RASSF1A, SRY, and GLO Sequences-Evaluation of Diagnostic Possibilities for Predicting Placental Insufficiency (en)
skos:prefLabel	Quantification of Extracellular DNA Using Hypermethylated RASSF1A, SRY, and GLO Sequences-Evaluation of Diagnostic Possibilities for Predicting Placental Insufficiency Quantification of Extracellular DNA Using Hypermethylated RASSF1A, SRY, and GLO Sequences-Evaluation of Diagnostic Possibilities for Predicting Placental Insufficiency (en)
skos:notation	RIV/00064203:_____/10:6259!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vlk, Radovan Doucha, Jindřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	283612
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/10:6259
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	free fetal dna; noninvasive prenatal-diagnosis; quantitative pcr measurement; maternal plasma; growth restriction; pregnant-women; preeclampsia; abnormalities; elevation; marker (en)
http://linked.open.../riv/klicoveSlovo	free fetal dna abnormalities marker maternal plasma pregnant-women noninvasive prenatal-diagnosis quantitative pcr measurement growth restriction elevation preeclampsia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9372E985E42E]
http://linked.open...i/riv/nazevZdroje	DNA and Cell Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Jancuskova, T. Hromadníková, I. Doucha, Jindřich Kotlabova, K. Dlouha, K. Vlk, Radovan Zejskova, L. Jirasek, J. E Krofta, L.
http://linked.open...ain/vavai/riv/wos	000278871500004
issn	1044-5498
number of pages	7 (xsd:int)

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