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Description
| - We aimed at characterizing the pharmacokinetics for daunorubicin in infants with ALL and examined their relationship to age, body weight, and body surface area. No age-dependency in any of the BSA-normalized pharmacokinetic parameters was observed. Consequently, due to the empirical dose reduction in infants the overall exposure to daunorubicinol in infants was smaller than would be expected from older children. We observed no indication of an age-dependency in the pharmacokinetics of daunorubicin.
- We aimed at characterizing the pharmacokinetics for daunorubicin in infants with ALL and examined their relationship to age, body weight, and body surface area. No age-dependency in any of the BSA-normalized pharmacokinetic parameters was observed. Consequently, due to the empirical dose reduction in infants the overall exposure to daunorubicinol in infants was smaller than would be expected from older children. We observed no indication of an age-dependency in the pharmacokinetics of daunorubicin. (en)
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Title
| - Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol
- Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol (en)
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skos:prefLabel
| - Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol
- Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol (en)
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skos:notation
| - RIV/00064203:_____/10:6069!RIV11-MZ0-00064203
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064203:_____/10:6069
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - daunorubicin; infants; leukemia; pharmacokinetics; acute lymphoblastic-leukemia; risk-factors; model; therapy; cardiotoxicity; quantification; doxorubicin; ly335979 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pieters, R.
- Starý, Jan
- De Lorenzo, P.
- Valsecchi, MG
- Hempel, G.
- Barisone, E.
- Boos, J.
- Relling, M. V.
- de Rossi, G.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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