About: Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia

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About: Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mutations of WT1 gene were found in diagnostic pediatric AML samples. WT1 mutations conferred an independent poor prognostic significance WT1 mutations conferred an independent poor prognostic significance (WT1 mutated vs wild-type patients: 5-year probability of overall survival [pOS] 35% vs 66%, P = .002; probability of event-free survival 22% vs 46%, P < .001; and cumulative incidence of relapse or regression 70% vs 44%, P < .001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker. Mutations of WT1 gene were found in diagnostic pediatric AML samples. WT1 mutations conferred an independent poor prognostic significance WT1 mutations conferred an independent poor prognostic significance (WT1 mutated vs wild-type patients: 5-year probability of overall survival [pOS] 35% vs 66%, P = .002; probability of event-free survival 22% vs 46%, P < .001; and cumulative incidence of relapse or regression 70% vs 44%, P < .001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker. (en)
Title	Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia (en)
skos:prefLabel	Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia (en)
skos:notation	RIV/00064203:_____/09:5348!RIV10-MZ0-00064203
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	23
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Trka, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	307296
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/09:5348
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	wt1 gene; normal karyotype; nucleophosmin mutations; tandem duplication; treatment strategy; tumor-suppressor; drug-resistance; pediatric aml; trials; flt3 (en)
http://linked.open.../riv/klicoveSlovo	flt3 normal karyotype tumor-suppressor drug-resistance treatment strategy trials nucleophosmin mutations pediatric aml tandem duplication wt1 gene
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[94BC4C813769]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	113
http://linked.open...iv/tvurceVysledku	Arentsen-Peters, STCJM Balgobind, BV Baruchel, A. Creutzig, U. Hollink, IHIM Kaspers, GJL Pieters, R. Reinhardt, D. Trka, Jan Zimmermann, M. Zwaan, CM van den Heuvel-Eibrink, MM de Graaf, SSN Alders, M. Willasch, A.
http://linked.open...ain/vavai/riv/wos	000266656100038
issn	0006-4971
number of pages	10 (xsd:int)

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