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Description
| - Mutations of WT1 gene were found in diagnostic pediatric AML samples. WT1 mutations conferred an independent poor prognostic significance WT1 mutations conferred an independent poor prognostic significance (WT1 mutated vs wild-type patients: 5-year probability of overall survival [pOS] 35% vs 66%, P = .002; probability of event-free survival 22% vs 46%, P < .001; and cumulative incidence of relapse or regression 70% vs 44%, P < .001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker.
- Mutations of WT1 gene were found in diagnostic pediatric AML samples. WT1 mutations conferred an independent poor prognostic significance WT1 mutations conferred an independent poor prognostic significance (WT1 mutated vs wild-type patients: 5-year probability of overall survival [pOS] 35% vs 66%, P = .002; probability of event-free survival 22% vs 46%, P < .001; and cumulative incidence of relapse or regression 70% vs 44%, P < .001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker. (en)
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Title
| - Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
- Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia (en)
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skos:prefLabel
| - Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
- Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia (en)
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skos:notation
| - RIV/00064203:_____/09:5348!RIV10-MZ0-00064203
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064203:_____/09:5348
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - wt1 gene; normal karyotype; nucleophosmin mutations; tandem duplication; treatment strategy; tumor-suppressor; drug-resistance; pediatric aml; trials; flt3 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Arentsen-Peters, STCJM
- Balgobind, BV
- Baruchel, A.
- Creutzig, U.
- Hollink, IHIM
- Kaspers, GJL
- Pieters, R.
- Reinhardt, D.
- Trka, Jan
- Zimmermann, M.
- Zwaan, CM
- van den Heuvel-Eibrink, MM
- de Graaf, SSN
- Alders, M.
- Willasch, A.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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