About: Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine

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About: Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Savčí peroxidázy aktivují protinádorový lék elipticin, což umožňuje tvorbu deoxyguanozinových adduktů v DNA, které jsou shodné s addukty vyvolanými 12-hydroxyelipticinem a 13-hydroxyelipticinem in vivo (cs) Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation, inhibition of topoisomerase II and cytochrome P450-mediated formation of covalent DNA adducts. Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation, inhibition of topoisomerase II and cytochrome P450-mediated formation of covalent DNA adducts. (en)
Title	Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine Savčí peroxidázy aktivují protinádorový lék elipticin, což umožňuje tvorbu deoxyguanozinových adduktů v DNA, které jsou shodné s addukty vyvolanými 12-hydroxyelipticinem a 13-hydroxyelipticinem in vivo (cs) Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine (en)
skos:prefLabel	Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine Savčí peroxidázy aktivují protinádorový lék elipticin, což umožňuje tvorbu deoxyguanozinových adduktů v DNA, které jsou shodné s addukty vyvolanými 12-hydroxyelipticinem a 13-hydroxyelipticinem in vivo (cs) Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine (en)
skos:notation	RIV/00064203:_____/07:1577!RIV08-MSM-00064203
http://linked.open.../vavai/riv/strany	243-251
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/06/0329), Z(MSM0021620808), Z(MSM0021620813)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Eckschlager, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	431825
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/07:1577
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ellipticine; anticancer drug; peroxidase; cytochrome P450; DNA adduct; xenobiotic-metabolizing enzymes; covalent binding; breast-cancer; catalyzed activation; elliptinium acetate; mediated oxidation; cytochromes p450; antitumor agent; cell-line; sudan-i (en)
http://linked.open.../riv/klicoveSlovo	cell-line catalyzed activation elliptinium acetate mediated oxidation ellipticine breast-cancer covalent binding xenobiotic-metabolizing enzymes anticancer drug peroxidase cytochrome P450 antitumor agent DNA adduct sudan-i cytochromes p450
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[A8A0E5E91879]
http://linked.open...i/riv/nazevZdroje	International Journal of Cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on mechanism of antineoplastic action of an anticancer drug ellipticine
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	120
http://linked.open...iv/tvurceVysledku	Eckschlager, Tomáš
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu The Molecular Basis of Childhood Malignancies and Therapeutic Applications
issn	0020-7136
number of pages	9 (xsd:int)

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