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  • The aim of the study was to analyze menopausal changes in components of metabolic syndrome (MS) and the parameter of insulin resistance (HOMA-IR). A random population sample of 909 women aged 45–54 years was examined. RESULTS The prevalence of MS rose significantly in menopause (REPRO/POSTm 22.9+2.6% /38.3+4.0%; p<0.001). However, a detailed analysis showed among the five components defining MS that increases were only seen in waist circumference (p<0.0001) and triglycerides (p<0.001). A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, ns; high HOMA-IR 1.8/2.1, p<0.001) and an increase in the prevalence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMAIR 13.8%/18.7%, ns; high HOMA-IR 30.9%/57.3%, p<0.0001). CONCLUSION The acceleration of MS prevalence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk.
  • The aim of the study was to analyze menopausal changes in components of metabolic syndrome (MS) and the parameter of insulin resistance (HOMA-IR). A random population sample of 909 women aged 45–54 years was examined. RESULTS The prevalence of MS rose significantly in menopause (REPRO/POSTm 22.9+2.6% /38.3+4.0%; p<0.001). However, a detailed analysis showed among the five components defining MS that increases were only seen in waist circumference (p<0.0001) and triglycerides (p<0.001). A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, ns; high HOMA-IR 1.8/2.1, p<0.001) and an increase in the prevalence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMAIR 13.8%/18.7%, ns; high HOMA-IR 30.9%/57.3%, p<0.0001). CONCLUSION The acceleration of MS prevalence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk. (en)
Title
  • Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.
  • Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance. (en)
skos:prefLabel
  • Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.
  • Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance. (en)
skos:notation
  • RIV/00064190:_____/10:#0000025!RIV10-MZ0-00064190
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 270351
http://linked.open...ai/riv/idVysledku
  • RIV/00064190:_____/10:#0000025
http://linked.open...riv/jazykVysledku
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  • menopause; metabolic syndrome; central obesity; insulin resistance; cardiovascular disease; dyslipidemia; blood pressure (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E8A336DC2FBF]
http://linked.open...i/riv/nazevZdroje
  • Climacteric
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 13
http://linked.open...iv/tvurceVysledku
  • Lejsková, M.
http://linked.open...n/vavai/riv/zamer
issn
  • 1369-7137
number of pages
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