About: Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy

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Description	Introduction. Nonpharmacological treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM) comprises surgical myectomy (SME), alcohol septal ablation (ASA), and dual-chamber (DDD) pacing. The aim of the study was to compare the long-term effect of DDD pacing and ASA in symptomatic HOCM patients. Patients and Methods. We evaluated retrospective data from three cardiocenters; there were 24 patients treated with DDD pacing included and 52 treated with ASA followed for 101 +/- 49 and 87 +/- 23 months, respectively. Results. In the group treated with DDD pacing, the left ventricle outflow tract gradient (LVOTG) decreased from 82 +/- 44mmHg to 21 +/- 21mmHg, and NYHA class improved from 2.7 +/- 0.5 to 2.1 +/- 0.6 (both P < 0.001). In the ASA-treated group, a decline in LVOTG from 73 +/- 38mmHg to 24 +/- 26 mmHg and reduction in NYHA class from 2.8 +/- 0.5 to 1.7 +/- 0.8 were observed (both P < 0.001). The LVOTG change was similar in both groups (P = 0.264), and symptoms were more affected by ASA (P = 0.001). Conclusion. ASA and DDD pacing were similarly effective in reducing LVOTG. The symptoms improvement was more expressed in patients treated with ASA. Introduction. Nonpharmacological treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM) comprises surgical myectomy (SME), alcohol septal ablation (ASA), and dual-chamber (DDD) pacing. The aim of the study was to compare the long-term effect of DDD pacing and ASA in symptomatic HOCM patients. Patients and Methods. We evaluated retrospective data from three cardiocenters; there were 24 patients treated with DDD pacing included and 52 treated with ASA followed for 101 +/- 49 and 87 +/- 23 months, respectively. Results. In the group treated with DDD pacing, the left ventricle outflow tract gradient (LVOTG) decreased from 82 +/- 44mmHg to 21 +/- 21mmHg, and NYHA class improved from 2.7 +/- 0.5 to 2.1 +/- 0.6 (both P < 0.001). In the ASA-treated group, a decline in LVOTG from 73 +/- 38mmHg to 24 +/- 26 mmHg and reduction in NYHA class from 2.8 +/- 0.5 to 1.7 +/- 0.8 were observed (both P < 0.001). The LVOTG change was similar in both groups (P = 0.264), and symptoms were more affected by ASA (P = 0.001). Conclusion. ASA and DDD pacing were similarly effective in reducing LVOTG. The symptoms improvement was more expressed in patients treated with ASA. (en)
Title	Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy (en)
skos:prefLabel	Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy (en)
skos:notation	RIV/00064173:_____/13:#0000309!RIV14-MZ0-00064173
http://linked.open...avai/riv/aktivita	I P V
http://linked.open...avai/riv/aktivity	I, P(ED1.100/02/0123), P(NT11401), V
http://linked.open...iv/cisloPeriodika	Article ID 629650
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Gregor, P. Čurila, K.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	66235
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/13:#0000309
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	subaortic stenosis; pacemaker implantation; left-ventricular hypertrophy (en)
http://linked.open.../riv/klicoveSlovo	pacemaker implantation subaortic stenosis left-ventricular hypertrophy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1BDEADE84B4F]
http://linked.open...i/riv/nazevZdroje	The Scientific World Journal
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Implications of Sleep Apnea for the Pathophysiology of Hypertrophic Cardiomyopathy St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	-
http://linked.open...iv/tvurceVysledku	Gregor, Pavel Čurila, Karol
http://linked.open...ain/vavai/riv/wos	000327333400001
issn	1537-744X
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2013/629650

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