About: Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites     Goto   Sponge   NotDistinct   Permalink

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  • We confirmed co-localization of four breakpoints: 5q15, 5q33, 7q21.11 7q32.3 and FS in MDS patients. Their roles in clonal transformation are not yet fully characterized. However, tumor-suppressor genes and/or oncogenes are predicted to reside in these loci. Further microarray analyses of the affected chromosomal regions in combination with molecular-cytogenetic approaches will help to elucidate the degree of correlation with fragile sites.
  • We confirmed co-localization of four breakpoints: 5q15, 5q33, 7q21.11 7q32.3 and FS in MDS patients. Their roles in clonal transformation are not yet fully characterized. However, tumor-suppressor genes and/or oncogenes are predicted to reside in these loci. Further microarray analyses of the affected chromosomal regions in combination with molecular-cytogenetic approaches will help to elucidate the degree of correlation with fragile sites. (en)
Title
  • Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites
  • Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites (en)
skos:prefLabel
  • Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites
  • Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites (en)
skos:notation
  • RIV/00064173:_____/12:#0000384!RIV14-MZ0-00064173
http://linked.open...avai/riv/aktivita
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  • P(LC535), P(OC10043), V, Z(MSM0021620808), Z(MZ0UHKT2005), Z(MZ0VFN2005)
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  • 6
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  • 164441
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  • RIV/00064173:_____/12:#0000384
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  • chromosomal breakpoints; myelodysplastic syndrome (en)
http://linked.open.../riv/klicoveSlovo
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [CA52CF16E1B8]
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  • Leukemia Research
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  • 36
http://linked.open...iv/tvurceVysledku
  • Černá, Olga
http://linked.open...ain/vavai/riv/wos
  • 000302961400003
http://linked.open...n/vavai/riv/zamer
issn
  • 0145-2126
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.leukres.2012.02.006
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