About: The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease

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About: The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets. SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease. The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets. SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease. (en)
Title	The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease (en)
skos:prefLabel	The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease (en)
skos:notation	RIV/00064173:_____/10:00002431!RIV13-MZ0-00064173
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS9975)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Gojiš, Ondřej Líbalová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	285752
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/10:00002431
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor marker; steroid receptor coactivator 3 (en)
http://linked.open.../riv/klicoveSlovo	tumor marker steroid receptor coactivator 3
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D2689C38E1FC]
http://linked.open...i/riv/nazevZdroje	EJSO - European Journal of Surgical Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	DNA ploidy and selected biological markers value for treatment selection and its impact on clinical outcome in endometrial or ovarian carcinoma - prospective study.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Gojiš, Ondřej Líbalová, Pavla
http://linked.open...ain/vavai/riv/wos	000276678000002
issn	0748-7983
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejso.2009.08.002

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