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rdf:type
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Description
| - There are multiple sclerosis patiens who suffer from an aggressive course of the disease with severe relapses and rapid accumulation of disability adeqate treatment. In such cases high-dose immunoablation with autologuous haematopoietic stem cell transplantation (ASCT) may be considered. Our objective was toreport our experience with 26 multiple sclerosis patients treated with ASCT within the years 1998-2008. Twenty-six patients (Expanded Disability Status Scale 2.5-7.5 (median 6.0), multiple sclerosis duration 2-19 years (median 7) with aggresive multiple sclerosis underwent autologous haematopoietic stem cell transplantation. Stem cells were mobilized by high-dose cyclophosphamide and granulocyte colony-stimulating factor, BEAM( carmustine, cytarabine, melphalan) was used for immunoablation. Patients were evaluated at baseline and every six months post ASCT for adverse events and clinicaloutcome.
- There are multiple sclerosis patiens who suffer from an aggressive course of the disease with severe relapses and rapid accumulation of disability adeqate treatment. In such cases high-dose immunoablation with autologuous haematopoietic stem cell transplantation (ASCT) may be considered. Our objective was toreport our experience with 26 multiple sclerosis patients treated with ASCT within the years 1998-2008. Twenty-six patients (Expanded Disability Status Scale 2.5-7.5 (median 6.0), multiple sclerosis duration 2-19 years (median 7) with aggresive multiple sclerosis underwent autologous haematopoietic stem cell transplantation. Stem cells were mobilized by high-dose cyclophosphamide and granulocyte colony-stimulating factor, BEAM( carmustine, cytarabine, melphalan) was used for immunoablation. Patients were evaluated at baseline and every six months post ASCT for adverse events and clinicaloutcome. (en)
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Title
| - High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience
- High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience (en)
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skos:prefLabel
| - High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience
- High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience (en)
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skos:notation
| - RIV/00064173:_____/10:#0000053!RIV11-MZ0-00064173
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(1A8713), P(GD309/08/H079), P(NR9375), S, V, Z(MSM0021620849)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064173:_____/10:#0000053
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - aggresive, immunoablation, immunosuppresion, multiple sclerosis, stem cell (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kemlink, D.
- Kozák, Tomáš
- Pohlreich, D.
- Trněný, M.
- Vacková, B.
- Kobylka, P.
- Havrdová, E.
- Krasulová, E.
- Kovářová, I.
- Lhotáková, P.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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