About: High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There are multiple sclerosis patiens who suffer from an aggressive course of the disease with severe relapses and rapid accumulation of disability adeqate treatment. In such cases high-dose immunoablation with autologuous haematopoietic stem cell transplantation (ASCT) may be considered. Our objective was toreport our experience with 26 multiple sclerosis patients treated with ASCT within the years 1998-2008. Twenty-six patients (Expanded Disability Status Scale 2.5-7.5 (median 6.0), multiple sclerosis duration 2-19 years (median 7) with aggresive multiple sclerosis underwent autologous haematopoietic stem cell transplantation. Stem cells were mobilized by high-dose cyclophosphamide and granulocyte colony-stimulating factor, BEAM( carmustine, cytarabine, melphalan) was used for immunoablation. Patients were evaluated at baseline and every six months post ASCT for adverse events and clinicaloutcome. There are multiple sclerosis patiens who suffer from an aggressive course of the disease with severe relapses and rapid accumulation of disability adeqate treatment. In such cases high-dose immunoablation with autologuous haematopoietic stem cell transplantation (ASCT) may be considered. Our objective was toreport our experience with 26 multiple sclerosis patients treated with ASCT within the years 1998-2008. Twenty-six patients (Expanded Disability Status Scale 2.5-7.5 (median 6.0), multiple sclerosis duration 2-19 years (median 7) with aggresive multiple sclerosis underwent autologous haematopoietic stem cell transplantation. Stem cells were mobilized by high-dose cyclophosphamide and granulocyte colony-stimulating factor, BEAM( carmustine, cytarabine, melphalan) was used for immunoablation. Patients were evaluated at baseline and every six months post ASCT for adverse events and clinicaloutcome. (en)
Title	High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience (en)
skos:prefLabel	High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience High-dose immunoablation with autologos haematopoietic cell transplantation in aggressive multiple sclerosis: a single 10-year experience (en)
skos:notation	RIV/00064173:_____/10:#0000053!RIV11-MZ0-00064173
http://linked.open...avai/riv/aktivita	I P S V Z
http://linked.open...avai/riv/aktivity	I, P(1A8713), P(GD309/08/H079), P(NR9375), S, V, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozák, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	261547
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/10:#0000053
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aggresive, immunoablation, immunosuppresion, multiple sclerosis, stem cell (en)
http://linked.open.../riv/klicoveSlovo	stem cell multiple sclerosis aggresive immunoablation immunosuppresion
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E17D50848423]
http://linked.open...i/riv/nazevZdroje	Multiple Sclerosis
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	PhD program in neuroscience The role of autologous haematopoetic stem cells in neuroprotection and immunomodulation in malignant multiple sclerosis Pharmacogenomics - a promising way for reasonable and efficacious multiple sclerosis treatment
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Kemlink, D. Kozák, Tomáš Pohlreich, D. Trněný, M. Vacková, B. Kobylka, P. Havrdová, E. Krasulová, E. Kovářová, I. Lhotáková, P.
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	1352-4585
number of pages	9 (xsd:int)

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