About: Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.

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About: Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis). It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis). (en)
Title	Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. (en)
skos:prefLabel	Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. (en)
skos:notation	RIV/00064173:_____/10:#0000049!RIV11-MZ0-00064173
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10369)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bartoš, Aleš Čechová, Linda
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	248070
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/10:#0000049
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	magnetite nanoparticles, cerebrospinal fluid, Alzheimer disease (en)
http://linked.open.../riv/klicoveSlovo	Alzheimer disease cerebrospinal fluid magnetite nanoparticles
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A5BDB0216577]
http://linked.open...i/riv/nazevZdroje	Molecular Biosystems
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Čechová, Linda Krištofíková, Z. Řípová, D. Říčný, J. Gažová, Z. Antošová, A. Klaschka, J.
issn	1742-206X
number of pages	6 (xsd:int)

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