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| Description
| - Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography- confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 +- 10.2 vs 66.9 +- 10.2 years), or age at self-reported RBD onset (55.2 +- 11.7 vs 56.6 +- 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD
- Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography- confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 +- 10.2 vs 66.9 +- 10.2 years), or age at self-reported RBD onset (55.2 +- 11.7 vs 56.6 +- 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD (en)
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| Title
| - Family history of idiopathic REM behavior disorder a multicenter case-control study
- Family history of idiopathic REM behavior disorder a multicenter case-control study (en)
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| skos:prefLabel
| - Family history of idiopathic REM behavior disorder a multicenter case-control study
- Family history of idiopathic REM behavior disorder a multicenter case-control study (en)
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| skos:notation
| - RIV/00064165:_____/13:10192195!RIV14-MZ0-00064165
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00064165:_____/13:10192195
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - polysomnography; Parkinson disease; parent; parasomnia; familial disease; Alzheimer disease; Idiopathic REM sleep behavior disorder (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Šonka, Karel
- Postuma, RB
- Dauvilliers, Yves
- Jennum, Poul
- Arnulf, Isabelle
- Desautels, Alex
- Fantini, Maria Livia
- Ferini-Strambi, Luigi
- Frauscher, Birgit
- Högl, Birgit
- Leu-Semenescu, Smeranda
- Manni, Raffaele
- Miyamoto, Masayuki
- Miyamoto, Tomoyuki
- Montplaisir, Jacques
- Oertel, Wolfgang
- Pelletier, Amélie
- Puligheddu, Monica
- Terzaghi, Michele
- Unger, Marcus
- Wolfson, Christina
- Zucconi, Marco
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1212/WNL.0b013e318296e967
|
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