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| Description
| - Objectives: To investigate whether anti-herpesvirus antibodies are associated with serum cholesterol profiles in clinically isolated syndromes (CIS). Methods: Pre-treatment serum samples from 118 high-risk CIS patients were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) viral capsid antigen (VCA) and EBV nuclear antigen-1 (EBNA-1). A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) was obtained. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months after start of interferon-beta treatment Results: The study included 118 CIS patients (77 females, 41 males, 65.3% female; mean age: 28.1 +/- SD 8.1 years). Anti-EBV EBNA-1 antibody levels were associated with LDL-C (p = 0.009) and TC (p = 0.008) levels. Anti-CMV positivity status was associated with reduced time to relapse (p = 0.006) and the greater number of relapses (p = 0.009) in patients with high HDL-C. Anti-EBV VCA antibody levels were associated with greater number of new 12 lesions (p = 0.002) and with increased brain atrophy (p < 0.001) in patients with high LDL-C. Conclusions: Our results indicate that higher levels of anti-EBV EBNA-1 antibodies are associated with higher LDL-C and TC levels. Anti-CMV positive individuals have greater disease progression in the presence of higher HDL-C levels. Individuals with higher levels of anti-EBV VCA antibodies have greater progression on MRI measures in the presence of higher LDL-C.
- Objectives: To investigate whether anti-herpesvirus antibodies are associated with serum cholesterol profiles in clinically isolated syndromes (CIS). Methods: Pre-treatment serum samples from 118 high-risk CIS patients were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) viral capsid antigen (VCA) and EBV nuclear antigen-1 (EBNA-1). A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) was obtained. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months after start of interferon-beta treatment Results: The study included 118 CIS patients (77 females, 41 males, 65.3% female; mean age: 28.1 +/- SD 8.1 years). Anti-EBV EBNA-1 antibody levels were associated with LDL-C (p = 0.009) and TC (p = 0.008) levels. Anti-CMV positivity status was associated with reduced time to relapse (p = 0.006) and the greater number of relapses (p = 0.009) in patients with high HDL-C. Anti-EBV VCA antibody levels were associated with greater number of new 12 lesions (p = 0.002) and with increased brain atrophy (p < 0.001) in patients with high LDL-C. Conclusions: Our results indicate that higher levels of anti-EBV EBNA-1 antibodies are associated with higher LDL-C and TC levels. Anti-CMV positive individuals have greater disease progression in the presence of higher HDL-C levels. Individuals with higher levels of anti-EBV VCA antibodies have greater progression on MRI measures in the presence of higher LDL-C. (en)
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| Title
| - Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes
- Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes (en)
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| skos:prefLabel
| - Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes
- Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes (en)
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| skos:notation
| - RIV/00064165:_____/13:10191810!RIV14-MZ0-00064165
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - I, P(NT13237), Z(MSM0021620849)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00064165:_____/13:10191810
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Clinically isolated syndromes; Multiple sclerosis; Environmental factor interactions; Epstein-Barr virus; Cholesterol; Lipid (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Neuroimmunology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Havrdová, Eva
- Seidl, Zdeněk
- Vaněčková, Manuela
- Bergsland, Niels
- Horáková, Dana
- Krásenský, Jan
- Tamano-Blanco, Miriam
- Týblová, Michaela
- Zivadinov, Robert
- Ramasamy, Deepa P.
- Badgett, Darlene
- Ramanathan, Murali
- Weinstock-Guttman, Bianca
- Hagemeier, Jesper
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.jneuroim.2013.07.010
|
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