About: The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3389/fphar.2012.00055
Description	Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed to be only awaste product of the heme catabolic pathway at best, and a potentially toxic compound at worst; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases. Indeed, serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases, as well as to related diseases and risk factors such as arterial hypertension, diabetes mellitus, metabolic syndrome, and obesity. Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed to be only awaste product of the heme catabolic pathway at best, and a potentially toxic compound at worst; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases. Indeed, serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases, as well as to related diseases and risk factors such as arterial hypertension, diabetes mellitus, metabolic syndrome, and obesity. (en)
Title	The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases (en)
skos:prefLabel	The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases (en)
skos:notation	RIV/00064165:_____/12:13021!RIV13-MZ0-00064165
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP206/11/0836), P(LH11030), P(NS9770)
http://linked.open...iv/cisloPeriodika	Articles 55
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vítek, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	165971
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/12:13021
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Bilirubin; biliverdin; biliverdin reductase; cardiovascular disease; diabetes mellitus; metabolic syndrome; heme oxygenase; UGT1A1 (en)
http://linked.open.../riv/klicoveSlovo	Bilirubin cardiovascular disease diabetes mellitus - insulin resistance - ethiopathogenesis - diagnostic criteria - late complications - advanced age - treatment metabolic syndrome heme oxygenase UGT1A1 biliverdin biliverdin reductase
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[E42173A34CD4]
http://linked.open...i/riv/nazevZdroje	Frontiers in Pharmacology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Structural Study of Potentially Bioactive Bile Pigment Complexes: Relation to their Protective Function in Organisms Atherosclerosis in young patients - focus on early onset myocardial infarction and ischemic peripheral arterial disease- genetic and pathophysiological background, risk factors, prognosis and quality of life Experimental studies of potential antiproliferative effects of edible algae
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Vítek, Libor
issn	1663-9812
number of pages	7 (xsd:int)

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