About: Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens     Goto   Sponge   NotDistinct   Permalink

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Description
  • We analyzed a series of 16 liver biopsies of lysosomal acid lipase (LAL) deficiency of the cholesterol ester storage disease (CESD) type confirmed by enzyme testing and DNA sequencing to identify reliable criteria to improve the differential diagnosis between lysosomal accumulation of neutral lipids and non-lysosomal steatosis. The pathological diagnosis of CESD can be rapidly and effectively appreciated at the light microscopy level, even in routine fixed paraffin-embedded liver samples with immmunohistochemical staining for lysosomal markers.
  • We analyzed a series of 16 liver biopsies of lysosomal acid lipase (LAL) deficiency of the cholesterol ester storage disease (CESD) type confirmed by enzyme testing and DNA sequencing to identify reliable criteria to improve the differential diagnosis between lysosomal accumulation of neutral lipids and non-lysosomal steatosis. The pathological diagnosis of CESD can be rapidly and effectively appreciated at the light microscopy level, even in routine fixed paraffin-embedded liver samples with immmunohistochemical staining for lysosomal markers. (en)
Title
  • Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens
  • Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens (en)
skos:prefLabel
  • Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens
  • Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens (en)
skos:notation
  • RIV/00064165:_____/12:12691!RIV13-MZ0-00064165
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 131574
http://linked.open...ai/riv/idVysledku
  • RIV/00064165:_____/12:12691
http://linked.open...riv/jazykVysledku
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  • diagnostic recommendations; immunohistochemistry; liver biopsy; lysosomal acid lipase deficiency; lysosomal markers (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [1B020C2CEB34]
http://linked.open...i/riv/nazevZdroje
  • Histopathology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 60
http://linked.open...iv/tvurceVysledku
  • Elleder, Milan
  • Hůlková, Helena
http://linked.open...ain/vavai/riv/wos
  • 000304344300009
http://linked.open...n/vavai/riv/zamer
issn
  • 0309-0167
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