About: Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.cyto.2012.02.003
Description	Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and characterise its potential association with skin changes and SSc-related features.Adiponectin serum levels were similar between patients with SSc and healthy controls. Levels of serum adiponectin were negatively correlated with the skin score. Regression analysis of the relationship between adiponectin and markers of interest provided two statistically significant models: A- with explanatory variables HDL-cholesterol, skin score, disease duration, age (R(2)=0.580); and B- with CRP, skin score, age in order of a decreasing influence. Based on the results of this study, it might be speculated that adiponectin plays a protective role in skin- and atherosclerosis-related changes during SSc Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and characterise its potential association with skin changes and SSc-related features.Adiponectin serum levels were similar between patients with SSc and healthy controls. Levels of serum adiponectin were negatively correlated with the skin score. Regression analysis of the relationship between adiponectin and markers of interest provided two statistically significant models: A- with explanatory variables HDL-cholesterol, skin score, disease duration, age (R(2)=0.580); and B- with CRP, skin score, age in order of a decreasing influence. Based on the results of this study, it might be speculated that adiponectin plays a protective role in skin- and atherosclerosis-related changes during SSc (en)
Title	Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis (en)
skos:prefLabel	Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis (en)
skos:notation	RIV/00064165:_____/12:12353!RIV13-MZ0-00064165
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Haluzík, Martin Běláček, Jaromír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	121112
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/12:12353
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adiponectin; systemic sclerosis; skin score (en)
http://linked.open.../riv/klicoveSlovo	skin score adiponectin systemic sclerosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4B599B2EED41]
http://linked.open...i/riv/nazevZdroje	Cytokine
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Filková, Mária Haluzík, Martin Kuklová, Markéta Vencovský, Jiří Šenolt, Ladislav Distler, O. Tomčík, Michal Gay, S. Bečvář, Radim Běláček, Jaromír Arima, Kazuhiko Braun, Martin Hulejova, Hana Müller-Ladner, U. Novák, Marek
http://linked.open...ain/vavai/riv/wos	000303099200006
issn	1043-4666
number of pages	4 (xsd:int)

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