About: Vascular disturbances in primary aldosteronism: Clinical evidence

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1159/000340031
Description	Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance. Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance. (en)
Title	Vascular disturbances in primary aldosteronism: Clinical evidence Vascular disturbances in primary aldosteronism: Clinical evidence (en)
skos:prefLabel	Vascular disturbances in primary aldosteronism: Clinical evidence Vascular disturbances in primary aldosteronism: Clinical evidence (en)
skos:notation	RIV/00064165:_____/12:11782!RIV13-MZ0-00064165
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Petrák, Ondřej Zelinka, Tomáš Holaj, Robert Šomlóová, Zuzana Štrauch, Branislav Widimský, Jiří Rosa, Ján
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	177063
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/12:11782
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Primary aldosteronism; Blood vessels; Abnormalities (en)
http://linked.open.../riv/klicoveSlovo	Blood vessels Abnormalities Primary aldosteronism
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[BC51D3B70C0D]
http://linked.open...i/riv/nazevZdroje	Kidney and Blood Pressure Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Petrák, Ondřej Rosa, Ján Widimský, Jiří jr. Zelinka, Tomáš Holaj, Robert Šomlóová, Zuzana Štrauch, Branislav
http://linked.open...ain/vavai/riv/wos	000314461100018
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění
issn	1420-4096
number of pages	5 (xsd:int)

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