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| rdf:type
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| rdfs:seeAlso
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| Description
| - Objective: To evaluate long-term effects of 2-year treatment with interferon beta combined with low-dose azathioprine and prednisone in multiple sclerosis. Methods: In the original 2-year ASA study, 181 patients with early relapsing-remitting multiple sclerosis were randomised into 3 treatment arms: those treated with interferon beta (n = 60), with interferon beta and low-dose azathioprine (n =58), and interferon beta, azathioprine and low-dose prednisone (n = 63). Of these, 172 were included in this 4-year non-study extension. Three monthly clinical controls and annual MRI scans were carried out. The primary endpoint was annual relapse activity. The secondary endpoints were disability and quantitative MRI parameters. Results: Nine patients were lost to follow-up and 172 were included in the analyses. None of relapse activity, disability accumulation or MRI parameters differed significantly between the groups over 6 years. Only 5.5% and 0.6% of patients were free from disease activity at year 2 and year 6 of the treatment initiation. Conclusion: The tested combined therapeutic regimen does not improve long-term outcomes in patients with multiple sclerosis. Furthermore, interferon is not able to completely abolish disease activity.
- Objective: To evaluate long-term effects of 2-year treatment with interferon beta combined with low-dose azathioprine and prednisone in multiple sclerosis. Methods: In the original 2-year ASA study, 181 patients with early relapsing-remitting multiple sclerosis were randomised into 3 treatment arms: those treated with interferon beta (n = 60), with interferon beta and low-dose azathioprine (n =58), and interferon beta, azathioprine and low-dose prednisone (n = 63). Of these, 172 were included in this 4-year non-study extension. Three monthly clinical controls and annual MRI scans were carried out. The primary endpoint was annual relapse activity. The secondary endpoints were disability and quantitative MRI parameters. Results: Nine patients were lost to follow-up and 172 were included in the analyses. None of relapse activity, disability accumulation or MRI parameters differed significantly between the groups over 6 years. Only 5.5% and 0.6% of patients were free from disease activity at year 2 and year 6 of the treatment initiation. Conclusion: The tested combined therapeutic regimen does not improve long-term outcomes in patients with multiple sclerosis. Furthermore, interferon is not able to completely abolish disease activity. (en)
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| Title
| - Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort
- Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort (en)
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| skos:prefLabel
| - Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort
- Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort (en)
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| skos:notation
| - RIV/00064165:_____/12:11753!RIV13-MZ0-00064165
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - Z(MSM0021620849), Z(MZ0VFN2005)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00064165:_____/12:11753
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Disease-modifying drugs; Immunosuppressants; Relapse; Disability; MRI; Clinical trial; Randomised; relapsing-remitting ms; combination therapy; disease-activity; brain atrophy; methylprednisolone; trial; beta; efficacy; safety (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Clinical Neurology and Neurosurgery
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Havrdová, Eva
- Seidl, Zdeněk
- Vaněčková, Manuela
- Horáková, Dana
- Krásenský, Jan
- Doležal, Ondřej
- Kalinčík, Tomáš
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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