About: Underlying mechanisms of ovarian cancer risk reduction after tubal ligation

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About: Underlying mechanisms of ovarian cancer risk reduction after tubal ligation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1111/j.1600-0412.2011.01114.x
Description	A recently published meta-analysis of 21 studies confirmed a protective effect of tubal ligation on the risk of invasive ovarian cancer. This protective measure has received little attention, particularly due to the elusive underlying mechanism. In this commentary we discuss available data concerning the contribution of different potential mechanisms by which tubal ligation might prevent ovarian cancer. Included were studies published in English, identified through a literature search using PubMed and EMBASE. Four main mechanisms are discussed: (a) a screening effect, (b) alteration of ovarian function, (c) a mechanical barrier against ascending carcinogenic agents and (d) prevention of endometrial and proximal Fallopian tube cell ascent. There are arguments supporting the major role of a mechanical barrier to the ascent of endometrial cells into the peritoneal cavity for decreasing risk of ovarian cancer after tubal ligation. Prevention of retrograde transport of carcinogenic substances from the vagina may be an additional mechanism. A recently published meta-analysis of 21 studies confirmed a protective effect of tubal ligation on the risk of invasive ovarian cancer. This protective measure has received little attention, particularly due to the elusive underlying mechanism. In this commentary we discuss available data concerning the contribution of different potential mechanisms by which tubal ligation might prevent ovarian cancer. Included were studies published in English, identified through a literature search using PubMed and EMBASE. Four main mechanisms are discussed: (a) a screening effect, (b) alteration of ovarian function, (c) a mechanical barrier against ascending carcinogenic agents and (d) prevention of endometrial and proximal Fallopian tube cell ascent. There are arguments supporting the major role of a mechanical barrier to the ascent of endometrial cells into the peritoneal cavity for decreasing risk of ovarian cancer after tubal ligation. Prevention of retrograde transport of carcinogenic substances from the vagina may be an additional mechanism. (en)
Title	Underlying mechanisms of ovarian cancer risk reduction after tubal ligation Underlying mechanisms of ovarian cancer risk reduction after tubal ligation (en)
skos:prefLabel	Underlying mechanisms of ovarian cancer risk reduction after tubal ligation Underlying mechanisms of ovarian cancer risk reduction after tubal ligation (en)
skos:notation	RIV/00064165:_____/11:10148!RIV12-MZ0-00064165
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zikán, Michal Cibula, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	236792
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/11:10148
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cancer prevention; ovarian cancer; tubal ligation; states case-control; collaborative analysis; reproductive history; epithelial tumors; cosmetic talc; white women; sterilization; hysterectomy; carcinoma; exposure (en)
http://linked.open.../riv/klicoveSlovo	carcinoma Cancer prevention collaborative analysis cosmetic talc epithelial tumors hysterectomy reproductive history states case-control tubal ligation white women sterilization exposure ovarian cancer
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[9032B2CBE877]
http://linked.open...i/riv/nazevZdroje	Acta Obstetricia et Gynecologica Scandinavica
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	90
http://linked.open...iv/tvurceVysledku	Cibula, David Dušek, L. Zikán, Michal Widschwendter, M.
http://linked.open...ain/vavai/riv/wos	000291433600002
issn	0001-6349
number of pages	5 (xsd:int)

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