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Description
| - Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality. This prospective, randomized, open-label, single-centre clinical trial included 150 patients with SIRS/sepsis and a SOFA score of > 5. Patients in the Se+ group (n = 75) received Se for 14 days (1,000 mu g on day 1,500 mu g/day on days 2-14).
- Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality. This prospective, randomized, open-label, single-centre clinical trial included 150 patients with SIRS/sepsis and a SOFA score of > 5. Patients in the Se+ group (n = 75) received Se for 14 days (1,000 mu g on day 1,500 mu g/day on days 2-14). (en)
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Title
| - High-dose selenium substitution in sepsis: a prospective randomized clinical trial
- High-dose selenium substitution in sepsis: a prospective randomized clinical trial (en)
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skos:prefLabel
| - High-dose selenium substitution in sepsis: a prospective randomized clinical trial
- High-dose selenium substitution in sepsis: a prospective randomized clinical trial (en)
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skos:notation
| - RIV/00064165:_____/11:10089!RIV12-MZ0-00064165
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064165:_____/11:10089
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Selenium; Systemic inflammatory response syndrome; Sepsis; Organ failure; Glutathione peroxidase; C-reactive protein; Procalcitonin; Prealbumin; Antioxidants; critically-ill patients; systemic inflammatory response; sodium selenite; septic shock; antioxidant therapy; glutathione-peroxidase; acute-pancreatitis; selenoprotein-p; major burns; supplementation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brodská, Helena
- Valenta, Jiří
- Drábek, Tomáš
- Hendl, Jan
- Kazda, Antonín
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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