About: High-dose selenium substitution in sepsis: a prospective randomized clinical trial

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s00134-011-2153-0
Description	Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality. This prospective, randomized, open-label, single-centre clinical trial included 150 patients with SIRS/sepsis and a SOFA score of > 5. Patients in the Se+ group (n = 75) received Se for 14 days (1,000 mu g on day 1,500 mu g/day on days 2-14). Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality. This prospective, randomized, open-label, single-centre clinical trial included 150 patients with SIRS/sepsis and a SOFA score of > 5. Patients in the Se+ group (n = 75) received Se for 14 days (1,000 mu g on day 1,500 mu g/day on days 2-14). (en)
Title	High-dose selenium substitution in sepsis: a prospective randomized clinical trial High-dose selenium substitution in sepsis: a prospective randomized clinical trial (en)
skos:prefLabel	High-dose selenium substitution in sepsis: a prospective randomized clinical trial High-dose selenium substitution in sepsis: a prospective randomized clinical trial (en)
skos:notation	RIV/00064165:_____/11:10089!RIV12-MZ0-00064165
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Valenta, Jiří Brodská, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	202045
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/11:10089
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Selenium; Systemic inflammatory response syndrome; Sepsis; Organ failure; Glutathione peroxidase; C-reactive protein; Procalcitonin; Prealbumin; Antioxidants; critically-ill patients; systemic inflammatory response; sodium selenite; septic shock; antioxidant therapy; glutathione-peroxidase; acute-pancreatitis; selenoprotein-p; major burns; supplementation (en)
http://linked.open.../riv/klicoveSlovo	C-reactive protein Sepsis supplementation Glutathione peroxidase Antioxidants sodium selenite Organ failure Prealbumin Procalcitonin Selenium Systemic inflammatory response syndrome acute-pancreatitis antioxidant therapy critically-ill patients glutathione-peroxidase major burns selenoprotein-p septic shock systemic inflammatory response
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[284C21274849]
http://linked.open...i/riv/nazevZdroje	Intensive Care Medicine
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Brodská, Helena Valenta, Jiří Drábek, Tomáš Hendl, Jan Kazda, Antonín
http://linked.open...ain/vavai/riv/wos	000289291900012
issn	0342-4642
number of pages	8 (xsd:int)

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