About: Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment

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About: Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cystathionine beta-synthase knockout mouse exhibits severe liver injury that is not found in the human cystathionine beta-synthase deficiency (homocystinuria) disease. The hepatopathy observed in this model may offer an explanation for the failure of cbs (-/-) mice to respond to betaine or exhibit a hypercoagulative phenotype. It is concluded that although this model provides useful data on the biochemical sequelae of classical homocystinuria, it does not successfully recapitulate a number of important features of the human disease and its use for studying mechanisms in homocystinuria should be treated with caution as the hepatopathy produces changes which could influence the results. Cystathionine beta-synthase knockout mouse exhibits severe liver injury that is not found in the human cystathionine beta-synthase deficiency (homocystinuria) disease. The hepatopathy observed in this model may offer an explanation for the failure of cbs (-/-) mice to respond to betaine or exhibit a hypercoagulative phenotype. It is concluded that although this model provides useful data on the biochemical sequelae of classical homocystinuria, it does not successfully recapitulate a number of important features of the human disease and its use for studying mechanisms in homocystinuria should be treated with caution as the hepatopathy produces changes which could influence the results. (en)
Title	Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment (en)
skos:prefLabel	Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment (en)
skos:notation	RIV/00064165:_____/10:7704!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	2.III
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Krijt, Jakub Kožich, Viktor Elleder, Milan Sikora, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	252632
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:7704
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Betaine; Coagulation; Cystathionine; Cystathionine beta-synthase; Cystathionine gamma-lyase; Homocystinuria; Homocysteine; s-adenosylhomocysteine; birth prevalence; deficient mice; animal-model; liver; metabolism; hyperhomocysteinemia; methionine; expression; fibrosis (en)
http://linked.open.../riv/klicoveSlovo	deficient mice birth prevalence expression metabolism Homocysteine methionine Betaine liver Coagulation fibrosis Cystathionine Cystathionine beta-synthase Cystathionine gamma-lyase Homocystinuria animal-model hyperhomocysteinemia s-adenosylhomocysteine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EFFC93F73608]
http://linked.open...i/riv/nazevZdroje	Molecular Genetics and Metabolism
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	101
http://linked.open...iv/tvurceVysledku	Elleder, Milan Kožich, Viktor Krijt, Jakub Sikora, Jakub Maclean, Kenneth N. Allen, Robert H. Crnic, Linda S. Greiner, Lori S. Jiang, Hua Kraus, Eva Kraus, Jan Petr Stabler, Sally P
http://linked.open...ain/vavai/riv/wos	000283609600013
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1096-7192
number of pages	9 (xsd:int)

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