About: Mechanism of increased mortality in hemodialysed patients with periodontitis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Periodontitis significantly decreases survival in hemodialysed patients with end stage renal disease (ESRD). Periodontitis-related microorganisms spreading into the bloodstream are thought to impair blood rheological parameters - for example, increasing whole blood viscosity, aggregating blood elements, and decreasing blood flow - and thereby significantly accelerate systemic ar local diseases, impairing survival. We discuuss the ability of a prototypical pothogenic anaerobic polybacterial consortium to modulate and interfere with host immune responses and to enzymatically degrade host proteins, to bind to and cleave extracellular matrixproteins to invade intercelluarly as well as intracellularly, to promote vascular permeability, to disrupt polymorphnuclear leukocyte function, to cleave complement, and to degrade IgG heavy chains. To further elucidate these phenomena, studies involving detecting microorganism byproducts and monitoring blood rheological parameters are necessary Periodontitis significantly decreases survival in hemodialysed patients with end stage renal disease (ESRD). Periodontitis-related microorganisms spreading into the bloodstream are thought to impair blood rheological parameters - for example, increasing whole blood viscosity, aggregating blood elements, and decreasing blood flow - and thereby significantly accelerate systemic ar local diseases, impairing survival. We discuuss the ability of a prototypical pothogenic anaerobic polybacterial consortium to modulate and interfere with host immune responses and to enzymatically degrade host proteins, to bind to and cleave extracellular matrixproteins to invade intercelluarly as well as intracellularly, to promote vascular permeability, to disrupt polymorphnuclear leukocyte function, to cleave complement, and to degrade IgG heavy chains. To further elucidate these phenomena, studies involving detecting microorganism byproducts and monitoring blood rheological parameters are necessary (en)
Title	Mechanism of increased mortality in hemodialysed patients with periodontitis Mechanism of increased mortality in hemodialysed patients with periodontitis (en)
skos:prefLabel	Mechanism of increased mortality in hemodialysed patients with periodontitis Mechanism of increased mortality in hemodialysed patients with periodontitis (en)
skos:notation	RIV/00064165:_____/10:7372!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	N Z
http://linked.open...avai/riv/aktivity	N, Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Dušková, Jana Foltán, René Horká, Edita Hofmanová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	270172
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:7372
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Periodontitis; end stage disease; pathofysiology rheological parametrs; blood (en)
http://linked.open.../riv/klicoveSlovo	Periodontitis pathofysiology rheological parametrs blood end stage disease
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0F6FD4D76EC0]
http://linked.open...i/riv/nazevZdroje	Medical Hypotheses
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Foltán, René Šedý, Jiří Horká, Edita Dušková, Jana Špačková, Jana
http://linked.open...ain/vavai/riv/wos	000274564700046
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0306-9877
number of pages	3 (xsd:int)

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