About: Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives     Goto   Sponge   NotDistinct   Permalink

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Description
  • Neuronal nitric oxide synthase (nNOS) represents an important therapeutic target for the prevention of brain injury and the treatment of various neurodegenerative disorders. A series of trans-substituted amino pyrrolidinomethyl 2-aminopyridine derivatives (8-34) was designed and synthesized.
  • Neuronal nitric oxide synthase (nNOS) represents an important therapeutic target for the prevention of brain injury and the treatment of various neurodegenerative disorders. A series of trans-substituted amino pyrrolidinomethyl 2-aminopyridine derivatives (8-34) was designed and synthesized. (en)
Title
  • Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives
  • Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives (en)
skos:prefLabel
  • Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives
  • Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives (en)
skos:notation
  • RIV/00064165:_____/10:7219!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(1M0520), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika
  • 21
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 258473
http://linked.open...ai/riv/idVysledku
  • RIV/00064165:_____/10:7219
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • highly selective inhibitors; fetal hypoxia-ischemia; escherichia-coli; cerebral-palsy; molecular-mechanisms; dipeptide amides; s-nitrosylation; mice lacking; potent; model (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [F78142930405]
http://linked.open...i/riv/nazevZdroje
  • Journal of medicinal chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Martásek, Pavel
  • Li, Huiying
  • Poulos, Thomas L.
  • Roman, Linda J.
  • Silverman, Richard B.
  • Delker, Silvia L.
  • Ji, Haitao
http://linked.open...ain/vavai/riv/wos
  • 000283703000027
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-2623
number of pages
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