About: Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6)

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About: Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6) Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hip trauma and surgery are associated with systemic inflammatory reaction. However, little evidence exists about the role of IL-6. In order to assess the inflammatory response, we evaluated white blood cell (WBC) count, C-reactive protein (CRP) and IL-6 dynamics in sequential pre- and postsurgical samples collected from 125 elderly patients (mean age 78 +/- 9 years) undergoing osteosynthesis (OS) for extracapsular hip fractures (n = 69), hemiarthroplasty (HA) or urgent total hip arthroplasty for intracapsular fractures (UA) (n = 35), and elective total hip arthroplasty for osteoarthrosis (OA) (n = 21). Both preoperative CRP and IL-6 levels were higher in patients with intracapsular fractures. IL-6 levels reached peak values immediately after the surgery, while CRP peak levels were reached 48 h after the surgery. The overall inflammatory reaction was more intense in HA patients compared to the other subgroups. Hip trauma and surgery are associated with systemic inflammatory reaction. However, little evidence exists about the role of IL-6. In order to assess the inflammatory response, we evaluated white blood cell (WBC) count, C-reactive protein (CRP) and IL-6 dynamics in sequential pre- and postsurgical samples collected from 125 elderly patients (mean age 78 +/- 9 years) undergoing osteosynthesis (OS) for extracapsular hip fractures (n = 69), hemiarthroplasty (HA) or urgent total hip arthroplasty for intracapsular fractures (UA) (n = 35), and elective total hip arthroplasty for osteoarthrosis (OA) (n = 21). Both preoperative CRP and IL-6 levels were higher in patients with intracapsular fractures. IL-6 levels reached peak values immediately after the surgery, while CRP peak levels were reached 48 h after the surgery. The overall inflammatory reaction was more intense in HA patients compared to the other subgroups. (en)
Title	Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6) Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6) (en)
skos:prefLabel	Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6) Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6) (en)
skos:notation	RIV/00064165:_____/10:6937!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(NR8830), V, Z(MZ0VFN2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kvasnička, Jan Linhart, Aleš Krška, Zdeněk Kudrnová, Zuzana Zeman, Miroslav Trča, Stanislav Sedlář, Martin Malíková, Ivana Erhart, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	276563
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:6937
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	older age; hip trauma; early inflamatory response; interleukin - 6 (en)
http://linked.open.../riv/klicoveSlovo	older age interleukin early inflamatory response hip trauma
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[6929C2B4A94B]
http://linked.open...i/riv/nazevZdroje	Archives of Gerontology and Geriatrics
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Acute conditions in geriatric surgery
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Krška, Zdeněk Linhart, Aleš Mazoch, J. Zeman, Miroslav Kvasnička, Jan Kudrnová, Zuzana Trča, Stanislav Sedlář, Martin Malíková, Ivana Erhart, David
http://linked.open...ain/vavai/riv/wos	000278134400023
http://linked.open...n/vavai/riv/zamer	Diagnosis and treatment of inherited disorders II
issn	0167-4943
number of pages	6 (xsd:int)

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