About: Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy

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About: Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Anti-TRIB2 autoantibodies are prevalent in narcolepsy, the highest positivity was found in HLA-DQB1-0602 positive cases with cataplexy. Their presence is associated with duration of cataplexy, and therefore, depends on duration of illness. Anti- TRIB2 autoantibodies are strongly associated with narcolepsy close to cataplexy onset (less to 2.3 years). They was rarely found in cases without cataplexy or with distant onset. The paper brings further support for autoimmune aetiology of the disease, anti-TRIB2 autoantibodies destroy selectively hypothalamic neurons producing hypocretin/orexin. Anti-TRIB2 autoantibodies are prevalent in narcolepsy, the highest positivity was found in HLA-DQB1-0602 positive cases with cataplexy. Their presence is associated with duration of cataplexy, and therefore, depends on duration of illness. Anti- TRIB2 autoantibodies are strongly associated with narcolepsy close to cataplexy onset (less to 2.3 years). They was rarely found in cases without cataplexy or with distant onset. The paper brings further support for autoimmune aetiology of the disease, anti-TRIB2 autoantibodies destroy selectively hypothalamic neurons producing hypocretin/orexin. (en)
Title	Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy (en)
skos:prefLabel	Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy (en)
skos:notation	RIV/00064165:_____/10:6753!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Nevšímalová, Soňa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	247170
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:6753
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Human narcolepsy; Tribbles homolog 2 (TRIB2); autoantibody; anti-streptolysin O (ASO); hypocretin orexin; antibodies; diagnosis; sleep; mutation; uveitis; assay (en)
http://linked.open.../riv/klicoveSlovo	antibodies sleep Human narcolepsy Tribbles homolog 2 (TRIB2) anti-streptolysin O (ASO) hypocretin orexin diagnosis autoantibody assay mutation uveitis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C3C9B437883A]
http://linked.open...i/riv/nazevZdroje	Sleep
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Nevšímalová, Soňa Jennum, Poul Knudsen, Stine Mignot, Emmanuel Plazzi, Giuseppe Lin, Ling Kawashima, Minae Tanaka, Susumu
http://linked.open...ain/vavai/riv/wos	000279365600006
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0161-8105
number of pages	6 (xsd:int)

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