About: Levels of Circulating Biomarkers at Rest and after Exercise in Coronary Artery Disease Patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. The objective of our study was to investigate the response of selected markers to the physical exercise in CAD patients and healthy controls. At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin values were significantly lower in CAD patients and a nonsignificant tendency to lower levels of sRAGE was also noted. After exercise MMP-9 and BNP, increased significantly in both groups. Conclusions: CAD patients have elevated hs-CRP, AOPP, MMP-9 and BP - novel markers related to cardiovascular risk or left ventricular overload. Only MMP-9 and BNP increase significantly with exercise both in healthy individuals and CAD patients. As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. The objective of our study was to investigate the response of selected markers to the physical exercise in CAD patients and healthy controls. At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin values were significantly lower in CAD patients and a nonsignificant tendency to lower levels of sRAGE was also noted. After exercise MMP-9 and BNP, increased significantly in both groups. Conclusions: CAD patients have elevated hs-CRP, AOPP, MMP-9 and BP - novel markers related to cardiovascular risk or left ventricular overload. Only MMP-9 and BNP increase significantly with exercise both in healthy individuals and CAD patients. (en)
Title	Levels of Circulating Biomarkers at Rest and after Exercise in Coronary Artery Disease Patients Levels of Circulating Biomarkers at Rest and after Exercise in Coronary Artery Disease Patients (en)
skos:prefLabel	Levels of Circulating Biomarkers at Rest and after Exercise in Coronary Artery Disease Patients Levels of Circulating Biomarkers at Rest and after Exercise in Coronary Artery Disease Patients (en)
skos:notation	RIV/00064165:_____/10:6482!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kalousová, Marta Benáková, Hana Linhart, Aleš Škrha, Jan Zima, Tomáš Kuchynka, Petr Danzig, Vilém
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	268363
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:6482
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Coronary artery disease; Inflammation; Metalloproteinases; Natriuretic peptides; Oxidative stress (en)
http://linked.open.../riv/klicoveSlovo	Natriuretic peptides Oxidative stress Inflammation Coronary artery disease Metalloproteinases
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[AF7DB31162C0]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Kalousová, Marta Kittnar, Otomar Linhart, Aleš Zima, Tomáš Škrha, Jan Benáková, Hana Kuchynka, Petr Danzig, Vilém Míková, B.
http://linked.open...ain/vavai/riv/wos	000280363700010
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění
issn	0862-8408
number of pages	8 (xsd:int)

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