About: HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study     Goto   Sponge   NotDistinct   Permalink

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Description
  • DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether methylation changes in PCGT genes in normal tissue is able to predict the presence of cancer, we studied HOXA gene methylation in normal endometrium from premenopausal ovarian cancer patients and age-matched healthy controls without ovarian cancer. DNA methylation of HOXA9 and HOXA11 genes in normal endometrium was associated with ovarian cancer in an initial test set and this was subsequently confirmed in independent validation sample sets.
  • DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether methylation changes in PCGT genes in normal tissue is able to predict the presence of cancer, we studied HOXA gene methylation in normal endometrium from premenopausal ovarian cancer patients and age-matched healthy controls without ovarian cancer. DNA methylation of HOXA9 and HOXA11 genes in normal endometrium was associated with ovarian cancer in an initial test set and this was subsequently confirmed in independent validation sample sets. (en)
Title
  • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study
  • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study (en)
skos:prefLabel
  • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study
  • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study (en)
skos:notation
  • RIV/00064165:_____/09:4602!RIV10-MZ0-00064165
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 317891
http://linked.open...ai/riv/idVysledku
  • RIV/00064165:_____/09:4602
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ovarian cancer; methylation; HOXA; Mullerian duct; endometrium (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [9EBDF11455A3]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Cancer
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 125
http://linked.open...iv/tvurceVysledku
  • Zikán, Michal
  • Widschwendter, Martin
  • Apostolidou, Sophia
  • Arora, Rupali
  • Ayhan, Ayse
  • Fourkala, Evangelia O.
  • Frasco, Melissa A.
  • Jones, Allison A.
  • Pearce, Celeste Leigh
http://linked.open...ain/vavai/riv/wos
  • 000270750000029
issn
  • 0020-7136
number of pages
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