About: Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Globozoospermia, characterised by the presence of round spermatozoa lacking acrosomes in an ejaculate, is a known cause of male infertility. Semen analysis, including sperm chromatin structure assay, toluidine blue, chromomycin A3 and aniline blue staining and fluorescence in situ hybridisation, was performed in an infertile globozoospermic patient to establish to which extent these genetic factors contributed to his infertility. No spermatozoa capable of hyaluronan (HA) binding were detected in the HA binding assay. Increased rates of immature spermatozoa with defective replacement of histones by protamines, DNA breaks and disturbed chromatin integrity and sperm aneuploid for the sex chromosomes were observed. Intracytoplasmic sperm injection (ICSI) was used in three in vitro fertilisation (IVF) cycles, and enough morphologically well-developing embryos were obtained in each cycle. However, no pregnancy was achieved. The infertility of our couple, resistant to IVF/ICSI treatment, was most probably caused by a combination of male and female factors. Globozoospermia, characterised by the presence of round spermatozoa lacking acrosomes in an ejaculate, is a known cause of male infertility. Semen analysis, including sperm chromatin structure assay, toluidine blue, chromomycin A3 and aniline blue staining and fluorescence in situ hybridisation, was performed in an infertile globozoospermic patient to establish to which extent these genetic factors contributed to his infertility. No spermatozoa capable of hyaluronan (HA) binding were detected in the HA binding assay. Increased rates of immature spermatozoa with defective replacement of histones by protamines, DNA breaks and disturbed chromatin integrity and sperm aneuploid for the sex chromosomes were observed. Intracytoplasmic sperm injection (ICSI) was used in three in vitro fertilisation (IVF) cycles, and enough morphologically well-developing embryos were obtained in each cycle. However, no pregnancy was achieved. The infertility of our couple, resistant to IVF/ICSI treatment, was most probably caused by a combination of male and female factors. (en)
Title	Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report (en)
skos:prefLabel	Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report (en)
skos:notation	RIV/00027162:_____/14:#0001107!RIV15-MSM-00027162
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Rubeš, Jiří Rybář, Roman Vozdová, Miluše Přinosilová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	50741
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/14:#0001107
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Aneuploidy; chromatin integrity; globozoospermia; infertility; sperm maturation (en)
http://linked.open.../riv/klicoveSlovo	infertility chromatin integrity globozoospermia sperm maturation Aneuploidy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9E0EA2FF0F7C]
http://linked.open...i/riv/nazevZdroje	Andrologia
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Rubeš, Jiří Přinosilová, Petra Rybář, Roman Vozdová, Miluše Kloudová, S. Texl, P.
http://linked.open...ain/vavai/riv/wos	000342811000003
issn	0303-4569
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/and.12156

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