About: Causes and consequences of maternal age-related aneuploidy in oocytes: a review

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown. Different hypotheses regarding age-related aneuploidy rise have been presented, but so far none of them can explain its full mechanism. Age-related aneuploidy is more likely to result from complex events taking place during the entire period of germ cell development, than from the failure of one particular mechanism. Recent findings confirm that the spindle assembly checkpoint (SAC) does not control and correct kinetochore-microtubule attachments in oocytes, enabling further propagation of aneuploidy, which has occurred in the earlier phases of oogenesis. In this review we will discuss the following hypotheses: the %22limited oocyte pool%22 hypothesis, the %22two hits%22 hypothesis, weakened centromeric cohesion and cohesin loss, different functions of the spindle assembly checkpoint and finally, changes in global gene expression. Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown. Different hypotheses regarding age-related aneuploidy rise have been presented, but so far none of them can explain its full mechanism. Age-related aneuploidy is more likely to result from complex events taking place during the entire period of germ cell development, than from the failure of one particular mechanism. Recent findings confirm that the spindle assembly checkpoint (SAC) does not control and correct kinetochore-microtubule attachments in oocytes, enabling further propagation of aneuploidy, which has occurred in the earlier phases of oogenesis. In this review we will discuss the following hypotheses: the %22limited oocyte pool%22 hypothesis, the %22two hits%22 hypothesis, weakened centromeric cohesion and cohesin loss, different functions of the spindle assembly checkpoint and finally, changes in global gene expression. (en)
Title	Causes and consequences of maternal age-related aneuploidy in oocytes: a review Causes and consequences of maternal age-related aneuploidy in oocytes: a review (en)
skos:prefLabel	Causes and consequences of maternal age-related aneuploidy in oocytes: a review Causes and consequences of maternal age-related aneuploidy in oocytes: a review (en)
skos:notation	RIV/00027162:_____/13:#0001037!RIV14-GA0-00027162
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA523/09/0743), P(GAP502/12/2201)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Danylevska, Anna Šebestová, Jaroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	64436
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/13:#0001037
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aneuploidy; oocyte; maternal age; meiosis; spindle assembly checkpoint (en)
http://linked.open.../riv/klicoveSlovo	aneuploidy spindle assembly checkpoint oocyte maternal age meiosis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7CFA79592EAF]
http://linked.open...i/riv/nazevZdroje	VETERINARNI MEDICINA
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	The changes in important regulatory mechanisms of meiotically dividing mammalian oocytes induced by ageing. Změna důležitých regulačních mechanismů buněčného dělení při přechodu z meiózy do mitózy.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Danylevska, Anna Šebestová, Jaroslava
http://linked.open...ain/vavai/riv/wos	000318531100002
issn	0375-8427
number of pages	8 (xsd:int)

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