About: Effects of adjuvants on the immune response of pigs after intradermal administration of antigen

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The ability of different adjuvants to enhance immune responses to intradermal (ID) immunisation with a model antigen was studied in pigs. Immune responses were evaluated with respect to the intensity of systemic and mucosal antibody formation, their isotype characterisation and rate of cell-mediated immunity. These findings were compared with the intensity of adverse local reactions. Six groups of piglets were immunised with keyhole limpet haemocyanin (KLH) antigen alone or in combination with aluminium hydroxide or selected oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). Systemic specific antibody responses were significantly increased following ID administration of antigen together with any of the adjuvants used. IgG antibody responses were most pronounced after the first administration of antigen, being stimulated with both Freund's and Montanide ISA 206 adjuvants. The oil adjuvants also enhanced the cell-mediated immune responses and the levels of local IgA antibodies in the respiratory mucosa. On the other hand, they elicited more pronounced adverse local reactions The ability of different adjuvants to enhance immune responses to intradermal (ID) immunisation with a model antigen was studied in pigs. Immune responses were evaluated with respect to the intensity of systemic and mucosal antibody formation, their isotype characterisation and rate of cell-mediated immunity. These findings were compared with the intensity of adverse local reactions. Six groups of piglets were immunised with keyhole limpet haemocyanin (KLH) antigen alone or in combination with aluminium hydroxide or selected oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). Systemic specific antibody responses were significantly increased following ID administration of antigen together with any of the adjuvants used. IgG antibody responses were most pronounced after the first administration of antigen, being stimulated with both Freund's and Montanide ISA 206 adjuvants. The oil adjuvants also enhanced the cell-mediated immune responses and the levels of local IgA antibodies in the respiratory mucosa. On the other hand, they elicited more pronounced adverse local reactions (en)
Title	Effects of adjuvants on the immune response of pigs after intradermal administration of antigen Effects of adjuvants on the immune response of pigs after intradermal administration of antigen (en)
skos:prefLabel	Effects of adjuvants on the immune response of pigs after intradermal administration of antigen Effects of adjuvants on the immune response of pigs after intradermal administration of antigen (en)
skos:notation	RIV/00027162:_____/13:#0000962!RIV14-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1B44024), P(ED0006/01/01), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Nechvátalová, Kateřina Faldyna, Martin Levá, Lenka Kudláčková, Hana Krejčí, Josef Toman, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	71907
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/13:#0000962
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Adjuvant; Intradermal; Mucosal; Cell-mediated immunity; Pigs (en)
http://linked.open.../riv/klicoveSlovo	Intradermal Mucosal Pigs Cell-mediated immunity Adjuvant
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[89ED7119FDF1]
http://linked.open...i/riv/nazevZdroje	Research in Veterinary Science
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Methods of the efficiency improvement of vaccination procedures in farm animals. Center for Advanced Microbiology & Immunology Research in Veterinary Medicine
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	94
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Levá, Lenka Nechvátalová, Kateřina Krejčí, Josef Kudláčková, Hana Toman, Miroslav Bernardy, J.
http://linked.open...ain/vavai/riv/wos	000319028000012
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0034-5288
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.rvsc.2012.07.021

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